By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

Objective / Purpose:

The Senior Scientist will play a pivotal role in Takeda’s “Lab of the Future” initiative, building a capability to provide robust cell lines, at scale, to enable the execution of robust cellular assays on fully automated, integrated platforms. The Senior Scientist will partner closely with Drug Discovery Units (DDUs), Lead Profiling, and automation engineering to help design, build and leverage an automated infrastructure to supply cells to scientists running assays to drive Takeda’s DMTA cycle. In this role you will:

Accelerate Discovery through Automation and AI-Integrated DMTA: Support the design and execution of cellular assays in 384- and 1,536-well formats on fully automated, robotic platforms with robust processes to ensure delivery of consistent cells through continuous culture or cryopreservation.Help create an infrastructure that operates in a highly efficient way, leveraging state-of-the-art automation and technology.Drives Cross-Functional Impact: Partners with DDUs, Lead Profiling, and data science teams to interpret cellular data in the context of SAR, disease biology, and mechanism-of-action, informing compound progression and portfolio decisions.

Accountabilities:

Advance Automated Cell Culture

Design, develop, optimize, and validate cellular automation platforms to enable continuous culture and large-scale cell banks.Partner with assay designers to drive assay miniaturization to 1,536-well formats, ensuring robustness, reproducibility, and biological relevance.

Drive Quality and Efficiency

Ensure that all cell lines are appropriately QC’d and banked.Leverage automation to minimize manual culture and support an assay environment that runs 24/7Ensure that the most disease relevant cells lines are used to drive SARContribute to seamless integration of instrumentation with LIMS/ELN systems, scheduling software, and digital data pipelines to enable end-to-end automation.

Ensure Data Excellence & AI-Readiness

Apply advanced statistical analysis and visualization tools to assess assay robustness, variability, and data quality.Ensure datasets are standardized, curated, and appropriately annotated to support AI/ML-driven analytics and cross-program insights.Contribute to data governance practices that promote longitudinal learning across Takeda’s discovery portfolio.

Collaborate Across Takeda

Partner closely with DDUs, data sciences, translational sciences, and medicinal chemistry to advance program objectives.Communicate findings clearly in cross-functional forums and contribute to scientific discussions that shape portfolio decisions.Uphold Takeda’s values of Integrity, Fairness, Honesty, and Perseverance in all scientific and operational activities.

Education & Competencies (Technical and Behavioral):

Ph.D. in Cell Biology, Pharmacology, Oncology, Molecular Biology, Chemical Biology, or related discipline with at least 2+ years of industry experience ORM.S. with 8+ years; OR B.S. with 10+ years of relevant pharmaceutical or biotech R&D experience.Expert in cell culture, biobanking and cell line maintenanceSignificant experience in building and leveraging cell culture automation to support high throughput workflowsFamiliarity with developing, optimizing, and executing High Content Assays, and other assay modalities such as reporter gene, CTG, GPCR, HTRF, AlphaScreen, MSD, and qPCR for primary, secondary, and mechanistic profiling.Experience embedding AI/ML and advanced analytics into DMTA processes and decision-makingHands-on familiarity with scheduling software, LIMS/ELN, and data pipeline tools commonly used in automated labs.Proficiency in data analysis and figure generation using tools such as Dotmatics, Spotfire or GraphPad.Demonstrated ability to work independently and collaboratively in a highly matrixed, cross-functional environment while managing multiple priorities and contribute to mentoring or guiding junior scientific staff.

Proven track record of:

Hands-on experience with live-cell imaging platforms such as Incucyte for real-time monitoring of cell growth, morphology, and confluence kinetics.Design and implementation of cellular profiling workflows to track growth kinetics, passage number effects, and phenotypic drift over time.Deep understanding of media formulation, optimization, and supplementation strategies to support diverse cell types (primary, iPSC-derived, engineered lines).Experience establishing and maintaining automated cell expansion, passaging, and seeding workflows with tight control over cell health and consistency.

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$137,000.00 - $215,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

Objective / Purpose:

The Associate Director will play a pivotal role in Takeda’s “Lab of the Future” initiative, building a capability to provide robust cell lines, at scale, to enable the execution of robust cellular assays on fully automated, integrated platforms. The Associate Director will partner closely with Drug Discovery Units (DDUs), Lead Profiling, and automation engineering to design, build and leverage an automated infrastructure to supply cells to scientists running assays to drive Takeda’s DMTA cycle. In this role you will:

Accelerate Discovery through Automation and AI-Integrated DMTA: Support the design and execution of cellular assays in 384- and 1,536-well formats on fully automated, robotic platforms with robust processes to ensure delivery of consistent cells through continuous culture or cryopreservation.Build a team and infrastructure that operates in a highly efficient way, leveraging state-of-the-art automation and technology.Drives Cross-Functional Impact: Partners with DDUs, Lead Profiling, and data science teams to interpret cellular data in the context of SAR, disease biology, and mechanism-of-action, informing compound progression and portfolio decisions.

Accountabilities:

     

Advance Automated Cell Culture

Define and lead the strategy for design, development, and deployment of scalable cellular automation platforms to enable continuous culture and enterprise-level cell banking.Drive cross-functional alignment with assay development teams to enable robust miniaturization to 1,536-well formats, ensuring reproducibility, scalability, and biological relevance across automated workflows.

Drive Quality and Efficiency

Establish and oversee quality frameworks for cell line QC, banking, and lifecycle management to ensure consistency and reproducibility at scale.Leverage automation to minimize manual culture and support an assay environment that runs 24/7Define selection criteria for disease-relevant cellular models to ensure strong alignment with SAR and translational biology objectives.Contribute to seamless integration of instrumentation with LIMS/ELN systems, scheduling software, and digital data pipelines to enable end-to-end automation.

Ensure Data Excellence & AI-Readiness

Apply advanced statistical analysis and visualization tools to assess assay robustness, variability, and data quality.Ensure datasets are standardized, curated, and appropriately annotated to support AI/ML-driven analytics and cross-program insights.Contribute to data governance practices that promote longitudinal learning across Takeda’s discovery portfolio.

Collaborate Across Takeda

Partner closely with DDUs, data sciences, translational sciences, and medicinal chemistry to advance program objectives.Communicate findings clearly in cross-functional forums and contribute to scientific discussions that shape portfolio decisions.Uphold Takeda’s values of Integrity, Fairness, Honesty, and Perseverance in all scientific and operational activities.

Education & Competencies (Technical and Behavioral):

Ph.D. in Cell Biology, Pharmacology, Oncology, Chemical Biology, or related discipline with at least 6+ years of industry experience ORM.S. with 12+ years; OR B.S. with 14+ years of relevant pharmaceutical or biotech R&D experience.Deep expertise in cell biology, automated cell culture, and biobanking at scale, including primary, iPSC-derived, and engineered cell systemsSignificant experience in design and deployment of fully integrated, end-to-end automated cell culture and assay platforms to support high throughput workflowsHands-on experience developing, optimizing, and executing High Content Assays, with familiarity in other assay modalities such as reporter gene, CTG, GPCR, HTRF, AlphaScreen, MSD, and qPCR for primary, secondary, and mechanistic profiling.Working knowledge of integrated HTS automation systems and robotic platforms, including programming, configuring, and troubleshooting liquid handlers (e.g., Echo, Hamilton, Beckman, Agilent).Demonstrated experience integrating AI/ML-driven analytics into DMTA workflows and decision-making.Ability to leverage data science to link cell health, assay performance, and SAR insightsHands-on familiarity with scheduling software, LIMS/ELN, and data pipeline tools commonly used in automated labs.Proficiency in data analysis and figure generation using tools such as Dotmatics, Spotfire or GraphPad.Demonstrated ability to work independently and collaboratively in a highly matrixed, cross-functional environment while managing multiple priorities and contribute to mentoring or guiding junior scientific staff.

Prove track record of:

Building and deploying end-to-end cellular automation platforms supporting high-throughput screening (384/1536 formats)Establishing fit-for-purpose QC frameworks (cell identity, passage control, phenotypic stability, contamination)

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$154,400.00 - $242,550.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Vice President , Global Clinical Lead  - Solid Tumor in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

OBJECTIVES: 

Responsible for leading as the Global Clinical Lead a large solid tumor oncology franchise that encompass multiple late stage and early phase programs . Ensures ongoing review and agreement of the Therapy Area Strategy and associated documents formulated by the OTAU leader prior to their review and approval by appropriate governance committees.  Oversees the development and execution of the Integrated Disease Area Strategy (IDAS) and overall Integrated Global Development Plan (IGDP).  Responsible for review of synopses, other relevant clinical study documents and critical Study Results.  Provide leadership and oversight of specific OTAU related programs and if applicable other indication specific clinical leads. Responsible for providing guidance to TA leaders on regional specificities within Therapeutic Area.

ACCOUNTABILITIES: 

Clinical Development team participation and leadership Accountable to Oncology Clinical Science Head to provide strategic clinical input on assigned clinical studies.Consistent with the Takeda R&D Oncology  Therapeutic Area Unit strategy, goals and objectives, this leader will partner with the other key functions and leaders and members of Oncology Precision and Translational Medicine, Oncology Portfolio Strategy Group, Global Regulatory Affairs, Quantitative and Clinical Pharmacology, other  R&D Functional Line Oncology Therapeutic Area Leads, Global Product Launch Strategy Oncology Franchise Leads, Regional Oncology Franchise Leads, Oncology Drug Development Unit (DDU) and other Oncology extended leadership, to drive the alignment on global clinical research and development strategy as related to internal and external pipeline and non-pipeline initiatives for the Takeda R&D Oncology Community across all regionsPart of the Oncology Clinical Sciences Leadership Team providing key input in strategic planning and connectivity for the overall Oncology Clinical Sciences group Leads the Global Development Team (US, EU, and others) managing both the US/EU Development Team and the Japan/ China Development team for assigned compounds. In some cases may lead the US/EU Development Team but more likely will oversee the study physician and/or clinical scientist leads responsible for leading the team. Emphasis will be on insuring that the development teams are proactively identifying contingencies, potential risks and strategies to address future obstacles.Directs Development Team strategy and deliverables overseeing the Development Strategy, Clinical Development Plan and Clinical Protocols. Recommends scope, complexity and size, which influence the budget of all aspects of a program. Provides continual critical evaluation of the development strategy to maintain a state-of-the-art development plan that is competitive and consistent with the latest regulatory requirements, proactive identification of challenges, and development of contingency plans to meet them.Responsible for high impact global decisions: interpreting data from ongoing internal and external studies, assessing the medical and scientific implications and making recommendations that impact regional and global development such as “go/no go” decisions or modification of development plans or study designs that may have a significant impact on timelines or product labeling. Plans clinical development strategies in context of medical/clinical significance considering how a given product will fit in with current treatments, standard of care, and unmet medical need.Accountable for ensuring regional strategies and trade-offs in regional requirements are well articulated in the global strategy documentation and that stakeholders are appropriately briefed.Providing strategic input into global development strategies and plans for all compounds in OTAU. Providing clinical and strategic support to evaluation of external compounds (alliances and in-licensing opportunities)Primary interface with Medical Affairs team for strategy and to support of product commercial effortsContributing to the creation and maintenance of regional KOL networkProviding recommendations for GDT leader nominations and reviewers of external compounds as part of business development effortsLiaison with Clinical Operations and Project Management for co-ordination of logistics study planning and implementationSynopsis / Protocol Development, Study Execution, & Study Interpretation Consistent with membership of the Clinical Review Board Committee, responsible for critical review of synopses, protocols, IBs and relevant clinical documents relating to studies in assigned compounds. Trial Medical Monitoring Reviews and assesses overall safety information in conjunction with Pharmacovigilance and Medical Monitor of record for assigned compounds.External Interactions Oversees and leads all clinical science activities involved in interactions with FDA, other regulatory agencies and key opinion leaders relevant to assigned compounds. Responsible for evaluation of external interactions in the context of overall development strategies using complex problem solving in the region but in context of a global environment.Proactive identification of challenges and development of contingency plans as appropriate.Due Diligence, Business Development and Alliance Projects Responsible for evaluation of potential business development opportunities in the region but with the context of a global environment. Conducts due diligence evaluations, of clinical development plans for potential alliances and or in-licensing opportunities. Serves as clinical contact point for ongoing alliance projects and interface with partner to achieve Takeda’s strategic goals while striving to maintain good working relationship between Takeda and partner.Assigns and manages clinical science staff who are involved in many of these activities.Leadership, Task Force Participation, Upper Management Accountability Interacts directly with research division based on pertinent clinical and development expertise and in all aspects relating to assigned compound in regional area.  Leads TGRD internal teams and global cross-functional teams. Works with functional leadership to prioritize projects within the therapeutic area.Hires, manages, mentors, motivates, empowers, develops and retains staff to support assigned activities. Conducts performance reviews and drive goal setting and development planning.

EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: 

Experience

MD or combined MD/PhD or internationally recognized equivalent with minimum 15 years pharmaceutical research experience, including minimum 10 years late phase clinical development experience with a focus on medical oncology  Clinical Training and Clinical Experience in Hematology/Oncology and/or Medical Oncology especially  in solid tumor malignancies Strong depth of scientific and clinical understanding and experience in cancer biology especially in immune based therapies.Experience in conducting and/ or leading multiple clinical trials involving immune based therapies  Proven experience in successfully leading and supervising direct reports including several physicians, physician scientists, scientists within a clinical development team in a global matrix environment.Demonstrated ability to foster a high-performance culture and build organizational capabilities.Strong leadership commitment to diversity, equity and inclusion, with experience in creating an inclusive and collaborative team environment that leverages diverse perspectives.Previous experience in successfully leading several clinical development team/matrix team with responsibility for Global studies in multiple regions. Clinical Development experience beyond US/EUSolid and Multiple experience in preparing and interacting with multiple regulatory agencies including FDA, EMA, and others  Multiple NDA/MAA submission experienceProven ability to lead and manage highly trained medical, scientific, and technical professionals.Superior communication, strategic, interpersonal and negotiating skillsEnterprise level leadership with the ability to inspire, motivate and drive resultsExcellent communication both verbally and in writing and influencing skills, with the ability to engage, inspire, and influence stakeholders at all levels, including executive management and external partners.Ability to proactively predict issues and solve problemsAbility to drive decision-making within a multi-disciplinary, multi-regional, matrix teamsDiplomacy and positive influencing abilities across multinational business cultures

TRAVEL REQUIREMENTS:

Willingness to travel to various meetings or client sites, including overnight trips. Several international travels may be required.Requires approximately 25-35 % travel.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law

This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy. 

#LI-JT1

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$321,000.00 - $504,460.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

Objective / Purpose:

The Senior Scientist will play a pivotal role in Takeda’s “Lab of the Future” initiative, driving the design, miniaturization, and execution of robust bioanalytical assays on fully automated, integrated platforms. Leveraging advanced automation systems and statistical analysis, this individual will ensure high-throughput, reproducible, and high-quality data generation to support iterative AI-integrated Design–Make–Test–Analyze (DMTA) cycles for both small- and large-molecule discovery. The Senior Scientist will partner closely with DMPK, medicinal chemistry, data sciences, and automation engineering to translate complex bioanalytical data into actionable insights that accelerate portfolio progression and enable data-driven decision-making. This role contributes to critical function delivery as follows:

Accelerates Discovery through Automation and AI-Integrated DMTA: Designs and executes bioanalytical assays in 384- and 1,536-well formats on fully automated, robotic platforms with integrated workflows, enabling rapid, high-throughput testing and iterative optimization.Ensures Data Quality and Scientific Rigor: Applies statistical methodologies to evaluate assay performance (e.g., Z’ factor, variability metrics, curve-fit confidence) and maintains reproducibility and reliability of decision-enabling datasets.Drives Cross-Functional Impact: Partners with DMPK, medicinal chemistry, and data science teams to interpret bioanalytical data in the context of SAR, disease biology, and mechanism-of-action, informing compound progression and portfolio decisions.

Accountabilities:

Advance Automated Bioanalytical Lead Profiling

Design, develop, optimize, and validate bioanalytical assays supporting hit identification, hit-to-lead, and lead optimization programs for small and large molecules.Drive assay miniaturization to 384- and 1,536-well formats, ensuring robustness, reproducibility, and biological relevance.Implement statistically rigorous assay performance standards (e.g., Z’ factor, signal-to-background, CV, curve-fit quality metrics) to ensure data integrity and confidence in decision-making.

Enable Efficient DMTA Cycles

Execute DMTA lead profiling assays, ensuring reliable, timely delivery of high-quality MS data across small- and large-molecule modalities.Adapt and translate bioanalytical assays to high-throughput MS platforms (e.g., Acoustic MS, RapidFire MS, MALD-MS or other).Continuously improve workflows to shorten cycle times and increase throughput while maintaining quality.

Operate Within Fully Integrated, Automated Systems

Develop and execute assays on fully automated robotic platforms, including liquid handling systems, acoustic dispensing, and multimode detection technologies.Partner with automation engineers to design scalable, modular workflows aligned with Lab of the Future principles.Contribute to seamless integration of instrumentation with LIMS/ELN systems, scheduling software, and digital data pipelines to enable end-to-end automation.

Ensure Data Excellence & AI-Readiness

Apply advanced statistical analysis and visualization tools to assess assay robustness, variability, and data quality.Ensure datasets are standardized, curated, and appropriately annotated to support AI/ML-driven analytics and cross-program insights.Contribute to data governance practices that promote longitudinal learning across Takeda’s discovery portfolio.

Collaborate Across Takeda

Partner closely with DMPK, medicinal chemistry, data sciences, and translational sciences to advance program objectives.Communicate findings clearly in cross-functional forums and contribute to scientific discussions that shape portfolio decisions.Uphold Takeda’s values of Integrity, Fairness, Honesty, and Perseverance in all scientific and operational activities.

Education & Competencies (Technical and Behavioral):

Expected: Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with at least 2+ years of industry experience; OR M.S. with 8+ years; OR B.S. with 10+ years of relevant experience with pharmaceutical or biotech R&D.Deep hands-on expertise in high-throughput MS (e.g., acoustic MS, RapidFire MS, MALDI-MS or other platforms), with a track record of developing and running high-throughput MS assays.Proven expertience working with DMTA or screening workflows.Working knowledge of integrated HTS automation systems and robotic platforms, including programming, configuring, and troubleshooting liquid handlers (e.g., Echo, Hamilton, Beckman, Agilent).Hands-on familiarity with scheduling software, LIMS/ELN, and data pipeline tools commonly used in automated labs.Proficiency with MS data analysis tools and software; experience with scripting or data handling (e.g., Python, R, Spotfire) is a plus.Demonstrated ability to work independently and collaboratively in a highly matrixed, cross-functional environment while managing multiple priorities and contribute to mentoring or guiding junior scientific staff.

Proven track record of:

Developing and validating bioanalytical assays for drug discovery.Adapting bioanalytical assays to high-throughput MS platforms; including miniaturization, and automation-friendly assay design.Experience in high-content, high-throughput environments, including design-of-experiments (DoE) approaches for optimization.Familiarity with LIMS/ELN systems and data pipeline tools.Running assays on fully automated, robotic platforms in high-throughput environments.Successful miniaturization of assays to at least 384-well and preferably 1,536-well plate formats.

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA. 

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$137,000.00 - $215,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

Objective / Purpose:

The Senior Scientist will play a pivotal role in Takeda’s “Lab of the Future” initiative, driving the design, miniaturization, and execution of robust cellular assays on fully automated, integrated platforms. Leveraging advanced automation systems and statistical analysis, this individual will ensure high-throughput, reproducible, and high-quality data generation to support iterative AI-integrated Design–Make–Test–Analyze (DMTA) cycles for both small- and large-molecule discovery. The Senior Scientist will partner closely with Drug Discovery Units (DDUs), chemistry, data sciences, and automation engineering to translate complex cellular data into actionable insights that accelerate portfolio progression and enable data-driven decision-making. This role contributes to critical function delivery as follows:

Accelerates Discovery through Automation and AI-Integrated DMTA: Designs and executes cellular assays in 384- and 1,536-well formats on fully automated, robotic platforms with integrated workflows, enabling rapid, high-throughput testing and iterative optimization.Ensures Data Quality and Scientific Rigor: Applies statistical methodologies to evaluate assay performance (e.g., Z’ factor, S/B, curve-fit confidence) and maintains reproducibility and reliability of decision-enabling datasets.Drives Cross-Functional Impact: Partners with DDUs, chemistry, and data science teams to interpret cellular data in the context of SAR, disease biology, and mechanism-of-action, informing compound progression and portfolio decisions.

Accountabilities:

                                                                                                

Advance Automated Cellular Lead Profiling

Design, develop, optimize, and validate disease-relevant cellular assays supporting hit identification, hit-to-lead, and lead optimization programs in oncology and gastrointestinal diseases.Drive assay miniaturization to 384- and 1,536-well formats, ensuring robustness, reproducibility, and biological relevance.Implement statistically rigorous assay performance standards (e.g., Z’ factor, signal-to-background, CV, curve-fit quality metrics) to ensure data integrity and confidence in decision-making.

Enable Efficient DMTA Cycles

Deliver timely IC50 determinations and mechanistic cellular data to support iterative DMTA cycles across small- and large-molecule modalities.Interpret cellular data in the context of SAR, disease biology, and target mechanism to inform compound progression.Continuously improve workflows to shorten cycle times and increase throughput while maintaining quality.

Operate Within Fully Integrated, Automated Systems

Develop and execute assays on fully automated robotic platforms, including liquid handling systems, acoustic dispensing, high-content imaging, and multimode detection technologies.Partner with automation engineers to design scalable, modular workflows aligned with Lab of the Future principles.Contribute to seamless integration of instrumentation with LIMS/ELN systems, scheduling software, and digital data pipelines to enable end-to-end automation.

Ensure Data Excellence & AI-Readiness

Apply advanced statistical analysis and visualization tools to assess assay robustness, variability, and data quality.Ensure datasets are standardized, curated, and appropriately annotated to support AI/ML-driven analytics and cross-program insights.Contribute to data governance practices that promote longitudinal learning across Takeda’s discovery portfolio.

Collaborate Across Takeda

Partner closely with DDUs, data sciences, translational sciences, and medicinal chemistry to advance program objectives.Communicate findings clearly in cross-functional forums and contribute to scientific discussions that shape portfolio decisions.Uphold Takeda’s values of Integrity, Fairness, Honesty, and Perseverance in all scientific and operational activities.

Education & Competencies (Technical and Behavioral):

Expected: Ph.D. in Cell Biology, Pharmacology, Oncology, Gastroenterology, Chemical Biology, or related discipline with at least 2+ years of industry experience; OR M.S. with 8+ years; OR B.S. with 10+ years of relevant experience in pharmaceutical or biotech R&D.Hands-on experience developing, optimizing, and executing High Content Assays (HCA), with strong experience in GPCR and ion channel assay development and screening, and familiarity with assay modalities such as reporter gene, CTG, HTRF, AlphaScreen, NanoBRET, HiBiT, MSD, and qPCR for primary, secondary, and mechanistic profiling.Experience in hit-to-lead and lead optimization support, including interpreting cellular data in the context of SAR and portfolio strategy.Working knowledge of integrated HTS automation systems and robotic platforms, including programming, configuring, and troubleshooting liquid handlers (e.g., Echo, Hamilton, Beckman, Agilent).Experience embedding AI/ML and advanced analytics into DMTA processes and decision-makingHands-on familiarity with scheduling software, LIMS/ELN, and data pipeline tools commonly used in automated labs.Proficiency in data analysis and figure generation using tools such as Dotmatics, Spotfire or GraphPad.Demonstrated ability to work independently and collaboratively in a highly matrixed, cross-functional environment while managing multiple priorities and contribute to mentoring or guiding junior scientific staff.

Proven track record of:

Developing and validating cellular assays for drug discovery.Demonstrated strong experience in GPCR and ion channel assay development and screening, including hands-on expertise with FLIPR system platforms and automated patch-clamp technologies such as SyncroPatch 384PE in at least 384-well high-throughput formats.Proven experience working with small-molecule compound or CRISPR libraries in high-throughput screening (HTS) and lead optimization contexts.Strong statistical and analytical skills for assay quality assessment, including Z’, CV, signal-to-background, and curve-fit confidence.Running assays on fully automated, robotic platforms in high-throughput environments.Successful miniaturization of assays to at least 384-well and preferably 1,536-well plate formats.

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA. 

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$137,000.00 - $215,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

Objective / Purpose:

The Associate Scientist will play a critical role in advancing cellular lead profiling and iterative Design–Make–Test–Analyze (DMTA) activities across oncology and gastrointestinal disease programs. Operating within fully automated, integrated laboratory systems, this individual will develop and execute robust cell-based assays that generate high-quality, decision-enabling data for small- and large-molecule discovery. With strong expertise in statistical analysis to assess assay robustness and data quality, the Associate Scientist will ensure rigor, reproducibility, and efficiency across programs. Importantly, this role will play a key part in Takeda’s “Lab of the Future” initiative, driving implementation of highly efficient, AI-integrated DMTA cycles that accelerate innovation and enhance data-driven discovery. This role contributes to critical function delivery:

Accelerates Discovery Through Automation & AI Integration: Implements and operates fully automated, end-to-end assay workflows integrated with AI-enabled analytics to increase throughput, reduce variability, and shorten DMTA cycle times.Ensures Data Quality & Scientific Rigor: Applies statistical methodologies to evaluate assay performance (e.g., Z’, variability metrics, curve-fit confidence) and ensures high-integrity data that directly informs compound progression and portfolio decisions.Drives Cross-Functional Impact: Partners closely with chemistry, data sciences, and early discovery teams to translate complex cellular data into actionable insights, supporting timely and informed advancement of discovery programs.

Accountabilities:

Develop, miniaturize, optimize, and validate robust cell-based assays to 384 or 1536 well plate formats to support lead optimization programs across oncology and gastrointestinal disease areas.Generate high-quality, reproducible data to enable informed decision-making within iterative Design–Make–Test–Analyze (DMTA) cycles.Design and execute high-content imaging and multiparametric cellular assays for compound characterization and mechanistic profiling.Perform and ensure timely execution of IC50/EC50 determinations and communicate results effectively to program teams.Apply rigorous statistical analysis, curve fitting, and data visualization tools to interpret complex cellular datasets.Utilize automation platforms and laboratory instrumentation to improve assay throughput, consistency, and efficiency.Incorporate AI-enabled tools and advanced software packages where appropriate to enhance data analysis and compound prioritization.Collaborate closely with cross-functional teams including chemistry, data sciences, and early discovery to drive project progression.Interpret, summarize, and present research findings at internal meetings and external scientific conferences as needed.Sustain a high-performing and reliable laboratory environment by rigorously applying quality control standards, executing preventative maintenance of instrumentation, and ensuring strict adherence to established standard operating procedures (SOPs).

Education & Competencies (Technical and Behavioral):

Expected: Master’s degree in in Cell Biology, Immunology, Oncology, Pharmacology, or related discipline with 3+ years OR Bachelor’s degree with 5+ years of relevant industry experience in drug discovery (pharma/biotech).Demonstrated expertise in:Mammalian cell culture (primary cells, engineered lines, co-culture systems, adherent and suspension cells)Cell-based potency assaysDose-response curve generation and IC50/EC50 analysisHigh-content imaging platformsExperience working within DMTA-driven discovery workflows.Strong data analysis and curve-fitting skills.Familiarity with laboratory automation systems.Excellent organizational and communication skills.Proven experience in developing and/or evaluating novel small molecule and biologicsStays current with emerging scientific literature, competitive landscapes, and innovative technologies

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$103,500.00 - $162,690.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

Objective / Purpose:

The Associate Scientist will play a critical role in advancing high-throughput mass spectrometry screening and iterative Design–Make–Test–Analyze (DMTA) activities across small and large molecule programs. Operating within fully automated, integrated laboratory systems, this individual will develop and execute robust bioanalytical assays that generate high-quality, decision-enabling data for small and large molecule discovery. With strong expertise in statistical analysis to assess assay robustness and data quality, the Associate Scientist will ensure rigor, reproducibility, and efficiency across programs. Importantly, this role will play a key part in Takeda’s “Lab of the Future” initiative, driving implementation of highly efficient, AI-integrated DMTA cycles that accelerate innovation and enhance data-driven discovery. This role contributes to critical function delivery:

Accelerates Discovery Through Automation & AI Integration: Implements and operates fully automated, end-to-end assay workflows integrated with AI-enabled analytics to increase throughput, reduce variability, and shorten DMTA cycle times.Ensures Data Quality & Scientific Rigor: Applies statistical methodologies to evaluate assay performance (e.g., Z’, variability metrics, curve-fit confidence) and ensures high-integrity data that directly informs compound progression and portfolio decisions.Drives Cross-Functional Impact: Partners closely with DMPK, medicinal chemistry, data sciences, and early discovery teams to translate assay data into actionable insights, supporting timely and informed advancement of discovery programs.

Accountabilities:

Develop, miniaturize, optimize, and validate robust high-throughput MS workflows, with a primary focus on acoustic MS, RapidFire MS, MALDI-MS or similar platforms for small and large molecule biotherapeutic lead profiling.Generate high-quality, reproducible data to enable informed decision-making within iterative Design–Make–Test–Analyze (DMTA) cycles.Design and execute quantitative and qualitative bioanalytical assays at 384- or 1536-well scalePerform and ensure timely execution of MS detection assays and communicate results effectively to program teams.Apply rigorous statistical analysis, curve fitting, and data visualization tools to interpret complex datasets.Utilize automation platforms and laboratory instrumentation to improve assay throughput, consistency, and efficiency.Collaborate closely with cross-functional teams including DMPK, medicinal chemistry, data sciences, and early discovery to drive project progression.Interpret, summarize, and present research findings at internal meetings and external scientific conferences as needed.Sustain a high-performing and reliable laboratory environment by rigorously applying quality control standards, executing preventative maintenance of instrumentation, and ensuring strict adherence to established standard operating procedures (SOPs).Familiarity with LIMS/ELN systems.

Education & Competencies (Technical and Behavioral):

Master’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or related discipline with 3+ years OR Bachelor’s degree with 5+ years of relevant industry experience in drug discovery (pharma/biotech).Demonstrated expertise in:High-throughput MS platforms (Acoustic MS, RapidFire MS, MALDI-MS or other platforms)Method development, optimization, troubleshooting and routine operationExperience working within DMTA-driven discovery workflows.Proficiency with MS data analysis tools and software; experience with scripting or data handling (e.g., Python, R, Spotfire) is a plus.Familiarity with laboratory automation systems.Excellent organizational and communication skills.Proven experience in developing and/or evaluating novel small molecule and biologics.Demonstrated ability to work independently and collaboratively in a highly matrixed, cross-functional environment while managing multiple priorities.Stays current with emerging scientific literature, competitive landscapes, and innovative technologies

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$103,500.00 - $162,690.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Are you looking for a patient-focused, innovation-driven company to inspire you and empower you to shine? Join us as a Clinical Study Manager based remotely reporting to the Clinical Operations Leadership team.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to work towards their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, and work toward excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to provide Better Health and a Brighter Future to people around the world.

Here, you will be a necessary contributor to our inspiring, bold mission.

GOALS:

Lead study operational strategy and planning and oversee execution of clinical studies for an assigned clinical program(s), supporting clinical strategy defined in Clinical Development Plan.

In close collaboration with Clinical Operations Program Lead(s):

Oversee the execution of studies in assigned clinical program(s) in compliance with quality standards (including ICH GCP, local regulations and Takeda SOPs), on schedule and on budget.

Oversee Strategic Partners and/or other CROs and other 3rd party vendors to meet Takeda’s obligations described in ICH-GCP and Takeda’s business objectives.

The assigned clinical studies may be of low to medium level of complexity. More than one study and/or more than one program may be assigned.

ACCOUNTABILITIES:

Accountable for planning and operational strategy and execution for assigned clinical trials.
o Provides subject matter expertise and operational input into protocol synopsis, final protocol and other study related documents.
o Challenges study team to ensure operational feasibility, inclusive of patient and site burden.
o Validates budget and ensures impacts are adequately addressed.
o Participates in country and site feasibility/selection process, with a focus on providing country insights, corporate alignment and therapeutic expertise to ensure alignment between study execution plan and program strategy.
o Challenges study team to ensure timelines meet the needs of the clinical development plan.
o Ensure new team members and vendors are appropriately onboarded.

During Early Engagement with Strategic Partner(s) and/or other CROs, lead the development of the Operational Strategy in preparation for Operational Strategy Review; focus on ensuring accurate assumptions are applied and robust risk management plans are in place.

Provide oversight/support/guidance to Strategic partners/CRO to ensure study issues are addressed and resolved rapidly.

Responsible for study budget planning and management and accountable for external spend related to study execution. Works closely with Clinical Operations Program Leader(s), Global Program Management, and Finance to ensure on a regular basis that budgets, enrollment, and gaiting are accurate; Communicates study status, cost and issues to Clinical Operations Program Lead(s); serve as escalation point for third party vendors managed by Strategic Partner and/or other CROs.

Oversee Strategic Partners/CRO/vendor selection, budget and contract negotiation, and proper supervision of performance for all activities assigned to a Strategic Partner/CRO/vendor for assigned studies, including escalation of issues to governance committees when warranted.

Specific areas of sponsor oversight include, but are not limited to:
o Review and approval of key monitoring documents/plans, periodic review of outputs, decisions and actions related to monitoring.
o Review and endorsement of relevant study plans, as applicable.
o Study team meeting management and attendance when necessary; regular review of meeting agendas and minutes.
o Review of outcomes/actions related to protocol deviations review; primary purpose of review is to support the identification of trends across sites and/or the study.
o Documented review and monitoring of issues, risks and decisions at the study level and implementation of appropriate mitigation strategies.

In partnership with data management, review and pressure test all database timelines and plans; ensure strong linkage between the strategy (i.e., filing/registration, data generation, etc.) with the tactical plan for database lock and CSR.

Ensure studies are “inspection ready” at all times; may be involved in regulatory inspections by preparing for and/or attending the inspections.

EDUCATION AND EXPERIENCE:

BS/BA required, preferably in a health-related, life science area or technology-related fields or equivalent combination of education, training and experience.

Advanced degree(s) (e.g., Master or Doctorate) and relevant training or experience (e.g., fellowship. internships, etc.) may be considered to supplement experience requirements.

5 or more years’ experience in pharmaceutical industry and/or clinical research organization, including 3 or more years clinical study management/oversight, including significant study management support experience (e.g. clinical trial assistant/associate or lead CRA).

Experience could include either early phase clinical studies or Phase 2 and 3 studies and global/international studies or programs. Experience in more than one therapeutic area is advantageous.

Knowledge in global regulatory and compliance requirements for clinical research, including but not limited to US CFR, EU CTD, and ICH GCP. Awareness of local country requirements is also required.

Demonstrated successful experience in project/program management and matrix leadership.

Good communication skills.

Excellent teamwork, organizational, interpersonal, and problem-solving skills.

Fluent business English (oral and written).

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Massachusetts - Virtual

U.S. Base Salary Range:

$103,500.00 - $162,690.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsMassachusetts - Virtual

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

#LI-Remote

Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

OBJECTIVES/PURPOSE

Create and execute detailed test plans and UAT scripts based on business requirements and technical specifications to verify study/library functionality in EDC system and adherence to standards.Drive study database user acceptance testing activities in a role that requires leadership across multiple therapeutic areas and the ability to partner closely with internal/external stakeholders to ensure the quality of the study build in the EDC system.Collaborate with various vendors and cross functional teams to build to ensure accuracy of any integration.Ensure accurate delivery of study build with quality deliverables per specification. Participate in the development, maintenance and training rendered on activities around study build and best practices used by business.Network with key business stakeholders on refining and enhancing the activities around study to automate the study build and reduce the need for testing.Develop organizational knowledge of organizational clinical data standards, key data sources, systems and be a valuable resource to people in the company on how to effectively automate study build to pursue company objectives. Provides technical leadership on various aspects of clinical data flow including build APIs to various systems for data extraction and integration.Maintains SOPs, process maps and templates and timelines to support functions operational and oversight models.Defines and/or Leads functional Continuous Improvement initiatives, providing strategic direction and identifying key deliverables that meet timelines, budget, and are in alignment with company, departmental or functional requirements.Works cross-functionally to ensure the quality of the data in each database and on time delivery, as well as quality of other data deliverables.Lead UAT activities for studies and libraries in EDC system, including inbound integrations with an Agile Approach according to applicable SOPs (standard operating procedures) and processes.Develop UAT documentation such as Test Plans, UAT Scripts, UAT Summary Report and etc.Create and execute standardized test scripts for EDC components, inbound integrations, and data listings.Record and document test results and compare to expected results. Detect software and specifications failures, so that defects may be discovered and corrected.Lead and coordinate End User Testing Activities, ensure that End User Testers have required training and system access.Communicate actively with management and clinical teams about testing progress and challenges.Support special projects and automated testing activities, including tool identification for manual UAT script automation.Provide technical support, liaising with CDE for troubleshooting and system issue resolution.Collaborate with cross-functional teams and vendors to ensure integration accuracy.Demonstrate strong understanding of electronic data capture and clinical data management systems, clinical databases, data flow, and related infrastructure, with experience in/around EDC systems such as Veeva CDM

ACCOUNTABILITIES

Test Plan and Script Execution:

Create and execute detailed test plans and User Acceptance Testing (UAT) scripts, ensuring alignment with business requirements and technical specifications.Validate study/library functionality within EDC systems and confirm adherence to established standards.

Testing Strategy Development:

Develop and enhance testing strategies for EDC system study/library builds and integrations.

Stakeholder Collaboration:

Network with key stakeholders to refine and improve study build automation and testing reduction strategies.

Leadership in UAT Activities:

Lead UAT for studies and libraries, including inbound integrations, using an Agile approach and in accordance with SOPs and processes.Coordinate and oversee End User Testing activities, ensuring testers are adequately trained and have necessary system access.

UAT Documentation Development:

Develop comprehensive UAT documentation, including Test Plans, UAT Scripts, and UAT Summary Reports.

Standardized Test Script Creation:

Develop and execute standardized test scripts for EDC components, inbound integrations, and data listings.

Testing Results Analysis:

Record and document test results, comparing them to expected outcomes.Identify software and specification failures for timely defect resolution.

Communication and Reporting:

Actively communicate with management and clinical teams about testing progress, challenges, and outcomes.

Support for Special Projects:

Assist in special projects and automated testing initiatives, including the identification of tools for manual UAT script automation.

Technical Support and Troubleshooting:

Provide technical support, collaborating with Clinical Data Engineering (CDE) for system troubleshooing and issue resolution.

Cross-functional Collaboration:

Work closely with cross-functional teams and vendors to ensure accuracy and efficiency in system integrations.

Expertise in Clinical Data Systems:

Demonstrate in-depth knowledge of electronic data capture, clinical data management systems, and related infrastructure.Utilize experience with various EDC systems (e.g., Veeva CDMS, Rave) and related clinical research technologies (e.g., eCOA, IRT, RTSM).S and Rave, Veeva CDB, elluminate® Data Central, EHR, eCOA, IRT, RTSM, TSDV, CDR, MDR, SCE and adjacent systems.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: 

BS/BA or MS in a Life Science, Computer Science, IT, Engineering, or related field or analytical area with ~10 years of experience in a CRO/pharmaceutical environment with a proven and consistent record of proactive management and innovation.Experience with EDC and clinical data management systems.Familiarity with clinical research technologies (e.g., eCOA, IRT, RTSM).Experience in software testing and quality assurance.Proficiency in Agile methodologies and adherence to SOPs.Understanding of clinical data management processes and regulations.Strong problem-solving skills and attention to detail.Previous experience leading a medium to large organization and influencing senior-level management and key stakeholders is a plus.Proven track record of leading and driving business process transformation and organizational culture change as well as delivering on programs with complex business deliverables.

ADDITIONAL INFORMATION

Requires approximately 1 - 2 domestic trips annually and up to 1 international trip.Ability to sit and stand for long periods of time. Carrying, handling, and reaching for objects.Manual dexterity to operate office equipment i.e., computers, phones, etc.

This position is currently classified as “remote” by Takeda’s Hybrid and Remote Work policy

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Massachusetts - Virtual

U.S. Base Salary Range:

$154,400.00 - $242,550.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsMassachusetts - Virtual

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

#LI-Remote

Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Are you looking for a patient-focused, innovation-driven company to inspire you and empower you to shine? Join us as a Lead Clinical Study Manager based remotely reporting to the Clinical Operations Leadership team.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to work towards their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, and work toward excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to provide Better Health and a Brighter Future to people around the world.

Here, you will be a necessary contributor to our inspiring, bold mission.

GOALS:

Lead study operational strategy and planning and oversee execution of clinical studies for an assigned clinical program(s), supporting clinical strategy defined in Clinical Development Plan. In close collaboration with Clinical Operations Program Lead(s):

Oversee the execution of studies in assigned clinical program(s) in compliance with quality standards (including ICH GCP, local regulations and Takeda SOPs), on schedule and on budget.Oversee Strategic Partners and/or other CROs and other 3rd party vendors to meet Takeda’s obligations described in ICH-GCP and Takeda’s business objectives.

The assigned clinical studies may be high complexity and/or high risk, e.g. multiple indications, data safety monitoring boards and/or endpoint review committees, interim analyses, requiring the coordination of multiple vendors, or other special assessments. More than one study and/or more than one program may be assigned.

ACCOUNTABILITIES:

Accountable for planning and operational strategy and execution for assigned clinical trials.Provides subject matter expertise and operational input into protocol synopsis, final protocol and other study related documents.Challenges study team to ensure operational feasibility, inclusive of patient and site burdenValidates budget and ensures impacts are adequately addressed.Participates in country and site feasibility/selection process, with a focus on providing country insights, corporate alignment and therapeutic expertise to ensure alignment between study execution plan and program strategy.Challenges study team to ensure timelines meet the needs of the clinical development plan.Ensure new team members and vendors are appropriately onboarded.During Early Engagement with Strategic Partner(s) and/or other CROs, lead the development of the Operational Strategy in preparation for Operational Strategy Review; focus on ensuring accurate assumptions are applied and robust risk management plans are in place.Provide oversight/support/guidance to Strategic partners/CRO to ensure study issues are addressed and resolved rapidly.Responsible for study budget planning and management and accountable for external spend related to study execution.  Works closely with Clinical Operations Program Leader(s), Global Program Management, and Finance to ensure on a regular basis that budgets, enrollment, and gaiting are accurate; Communicates study status, cost and issues to Clinical Operations Program Lead(s); serve as escalation point for third party vendors managed by Strategic Partner and/or other CROs.Oversee Strategic Partners/CRO/vendor selection, budget and contract negotiation, and proper supervision of performance for all activities assigned to a Strategic Partner/CRO/vendor for assigned studies, including escalation of issues to governance committees when warranted.Specific areas of sponsor oversight include, but are not limited to:Review and approval of key monitoring documents/plans, periodic review of outputs, decisions and actions related to monitoringReview and endorsement of relevant study plans, as applicableStudy team meeting management and attendance when necessary; regular review of meeting agendas and minutesReview of outcomes/actions related to protocol deviations review; primary purpose of review is to support the identification of trends across sites and/or the studyDocumented review and monitoring of issues, risks and decisions at the study level and implementation of appropriate mitigation strategiesIn partnership with data management, review and pressure test all database timelines and plans; ensure strong linkage between the strategy (i.e., filing/registration, data generation, etc.) with the tactical plan for database lock and CSR.Ensure studies are “inspection ready” at all time; may be involved in regulatory inspections by preparing for and/or attending the inspections.Represent the Lead Clinical Study Manager role in functional initiatives or working groups. Help with onboarding and mentoring of new or junior CSMs.May assist the program COPL in his/her role, as required

EDUCATION AND EXPERIENCE:

BS/BA required preferably in a health-related, life science area or technology-related fields or equivalent combination of education, training and experience.Advanced degree(s) (e.g., Master or Doctorate) and relevant training or experience (e.g., fellowship. internships, etc.) may be considered to supplement experience requirements.6+ years’ experience in pharmaceutical industry and/or clinical research organization, including 4+ years clinical study management/oversight. Experience must include either early phase clinical studies or Phase 2 and 3 studies and global/international studies or programs. Experience in more than one therapeutic area is advantageous.Knowledge in global regulatory and compliance requirements for clinical research, including but not limited to US CFR, EU CTD, and ICH GCP. Awareness of local country requirements is also required.Demonstrated excellence in project/program management and matrix leadership.Excellent communication skills.Excellent teamwork, organizational, interpersonal, and problem-solving skills.Fluent business English (oral and written).

TRAVEL REQUIREMENTS:

Requires approximately 5-20 % travel, including overnight and international travel to other Takeda sites, strategic partners, and therapeutic area required travel.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Massachusetts - Virtual

U.S. Base Salary Range:

$116,000.00 - $182,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsMassachusetts - Virtual

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

#LI-Remote

Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

OBJECTIVES/PURPOSE:

The Oncology (ONC) Therapeutic Area Lead in DMPK&M will have strong scientific and strategic leadership to impact broad responsibilities on the pipeline, talent, and strategy. This role will supervise and lead a team of DMPK&M project representatives and Modeling & Simulation (M&S) scientists responsible for delivering on Takeda’s research pipeline in the ONC therapeutic area.

This role is responsible for oversight on the DMPK&M strategy of the ONC portfolio and ensures the execution of DMPK&M project plans, translation, and dose optimization strategies, as well as review of regulatory filings.

This role will participate in therapeutic area-driven discussions and partner with cross-functional stakeholders to align on Takeda’s strategic framework. Key deliverables will be contributing to portfolio strategy and global business operations within DMPK&M. 

Demonstrates leadership experience in guiding talented teams and is a key member of the Global DMPK&M leadership team that drives department strategy, creates a positive and effective department culture, and strengthens partnerships across the Research and Development organizations within Takeda.

Leads a team of DMPK project representatives and modeling scientists who have key scientific and strategic input to research projects to enable Takeda to meet its global research goals.

Accountable for strategic planning and scientific oversight of the discovery and development portfolio for the ONC therapeutic area.

Actively supports DMPK&M Head in strategic execution of DMPK&M Vision and Mission.

Drives the development of organizational culture and capabilities by building strong alliances across the Research and Development organizations within Takeda.

Scientific responsibilities:

Provides scientific leadership and strategic guidance on stage-appropriate questions related to DMPK&M to ensure the selection and development of clinical candidates with optimal drug development characteristics.

Builds and enhances an external network to keep a pulse on scientific developments, novel strategies, partnership opportunities, and the latest competitive and regulatory landscape, particularly in relation to the ONC therapeutic areas.

Advises, reviews, and approves, on behalf of DMPK&M, milestone presentations and PRC narratives. Oversees and participates in regulatory activities, including the review and approval of robust and fit-for-purpose submission packages in the ONC therapeutic area.

Strategic responsibilities:

Act as the DMPK&M functional representative in governance committees and discussions regarding prioritization, strategy, resources, timelines, and decision-making criteria.

As the DMPK&M ONC Therapeutic Area Lead, this role will facilitate the alignment of DMPK&M strategy with DDU and TAU portfolio goals.

Collaborate with DDU and TAU senior leaders, communicating needs, strategy, and execution plans, while consulting with DMPK leadership to ensure resources and goals are aligned.

Accountable for appropriate resourcing of project support by collaborating with the Global DMPK&M leadership team.

Resources and reviews in-licensing evaluations for their respective therapeutic area. 

Management responsibilities:

Actively attract, develop, and retain talent.

DIMENSIONS AND ASPECTS:

Technical/Functional (Line) Expertise

Comprehensive understanding of drug discovery and development, the pharmaceutical industry, DMPK&M science.

Leadership

Achieves success for Takeda by collaboratively working with partners across the organization.

Ability to work across functions, regions, and cultures.

Functional level leadership with the ability to inspire, motivate and drive results.

Excellent communicator can persuasively convey both ideas and data, verbally and in writing.

Proven skills as an effective team player who can engender credibility and confidence within and outside the company.

Ability to distill complex issues and ideas down to simple comprehensible terms.

Demonstrates leadership presence and confidence.

Embraces and demonstrates a diversity and inclusion mindset and role models these behaviors for the organization.

Builds teams across functions and geographies with individuals who have the right skills and experience to deliver on key organizational initiatives.

Invests time in helping others to enhance their skills and perform at a higher level.

Decision-making and Autonomy

Provides input to highly complex decisions that impacts functional area.

Accountable for decision making for designated function.

Ability to seek diverse input from multiple constituents and stakeholders to drive innovative solutions.

Ability to incorporate feedback and ensure decisions are implemented swiftly to yield flawless execution.

Accountable for providing input to and implementing vision and strategy for designated scope.

Interaction

Effectively navigates the changing external and internal environment and leads others through change by creating an inspiring and engaging workplace.

Cultivates a broad network of relationships throughout Takeda, with affiliates and external partners, in the industry and area of expertise.

Effectively represents function in negotiations with the ability to resolve conflict in a constructive manner.

Ability to build strong relationships and collaborate effectively with other interfacing Takeda functions.

Innovation

Forward thinking with the ability to recommend, influence on behalf of DMPK&M and implement continuous innovation.

Comfortable challenging the status quo and bringing forward innovative solutions.

Ability to take risks implementing innovative solutions, accelerating time to market.

Complexity

Ability to work in a global ecosystem (internal and external) with a high degree of complexity.

Ability to see and understand a broader, enterprise level perspective.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

PhD degree in a scientific discipline with 15+ years experience, MS with 21+ years experience, or BS with 23+ years experience including at least 9 years of Industry experience in pharmaceutical DMPK and modeling

Good understanding of the (NS, ONC or ONC) DDU/TAU project portfolio, disease indications, and typical DMPK&M considerations for patients

Deep drug discovery and development experience and profound DMPK&M expertise required.

Experience in managing preclinical scientists and preparation of INDs, CTDs, NDAs, and MAAs.

Proactive, innovative, with good problem-solving skills.

Exceptional leadership, coaching, employee development skills.

Ability to work strategically in a cross functional team and matrix environment.

In-depth knowledge of the functional area, business strategies, and the company’s goals.

Excellent written, presentation, and verbal communication skills.

A track record of sustained, significant scientific contributions in DMPK and modeling, as demonstrated by publications and presentations.

This position is currently classified as “ hybrid” in accordance with Takeda’s Hybrid and Remote Work policy.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$212,000.00 - $333,190.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Objective / Purpose:

The Head of Strategic Research Outsourcing serves as the enterprise‑level leader responsible for shaping and executing the long‑term external innovation and outsourcing strategy across Research. This role leads the organization’s efforts to design, govern, and optimize a global network of Contract Research Organizations (CROs) to advance Takeda’s discovery and preclinical research portfolio.

Operating at the intersection of science, business strategy, and external partnership management, this leader ensures that Takeda’s outsourced research model is a competitive advantage — enabling scalable innovation, operational excellence, and strategic alignment with evolving research priorities. The role has direct managerial responsibility for the teams overseeing early discovery chemistry, preclinical CRO management, and other outsourced research modalities, ensuring that each team is empowered, high‑performing, and future‑focused.

Accountabilities:

Strategic Leadership & Vision

Develop, own, and continuously refine Takeda’s long-range Strategic Research Outsourcing vision, ensuring alignment with Research, Therapeutic Area, and enterprise priorities.Anticipate emerging industry trends, scientific capabilities, global research hubs, and external innovation models to position Takeda at the forefront of strategic outsourcing.Drive the evolution from transactional vendor management to an integrated, strategic partner ecosystem.Drive Takeda’s CRO ecosystem towards a fully integrated and seamless operation model that will support an agilely enhanced research organization.

CRO Network Strategy & Governance

Architect and oversee a global CRO network covering early discovery chemistry, preclinical research, platform technologies, and emerging scientific capabilities.Establish enterprise‑level governance frameworks and operating models to ensure quality, compliance, efficiency, and scientific excellence.Lead strategic CRO selection based on innovation potential, geographic footprint, scientific strength, risk profile, and alignment with long‑term company objectives.

Partnership Development & Relationship Management

Serve as Takeda’s senior executive interface with strategic CRO partners, fostering collaboration, transparency, and joint long‑term planning.Build high‑level connections between Takeda leadership and CRO executives to strengthen innovation pipelines, capability development, and operational resilience.Negotiate strategic agreements and partnership roadmaps that enhance Takeda’s scientific agility and competitive positioning.

Portfolio & Scientific Integration

Ensure outsourced capabilities are best‑in‑class, scalable, and tightly integrated into internal research workflows.Collaborate with scientific leaders to identify capability gaps and determine when externalization is the optimal path.Oversee the scientific and operational performance of CROs, ensuring high‑quality data, timely delivery, and alignment with disease‑area strategies.

Risk Management & Operational Excellence

Identify strategic risks across the CRO ecosystem — including IP protection, dependency risks, geographic concentration, and business continuity — and lead mitigation strategies.Establish KPIs and performance frameworks that evaluate CROs on both operational and strategic dimensions.Drive continuous improvement efforts that enhance productivity, scientific innovation, and cost‑effectiveness.

Team Leadership & Organizational Development

Lead, develop, coach and inspire the leaders and teams responsible for CRO management across chemistry, preclinical research, and future outsourced modalities.Foster a culture of innovation, accountability, cross‑functional collaboration, and external‑ready execution.Build organizational capabilities required for next‑generation outsourced research (e.g., digital integration, data transparency, advanced analytics, new modality CRO ecosystems).Participate as member of the Strategic Operations Leadership Team.

Education & Competencies (Technical and Behavioral):

Education

Advanced degree (Ph.D. strongly preferred) in Chemistry, Life Sciences, or a related scientific discipline; MBA or equivalent business training is an asset.

Experience

12–15+ years of pharmaceutical/biotech R&D experience, including extensive leadership experience managing outsourced research or strategic partnerships.Demonstrated success designing and executing large‑scale outsourcing strategies across discovery or preclinical research.Prior responsibility for managing scientific teams and external partners across global geographies.

Technical Competencies

Deep understanding of discovery and preclinical R&D workflows, including externalized chemistry, pharmacology, DMPK, and related CRO capabilities.Expertise in vendor strategy, scientific operations, governance models, and partnership frameworks.Strong command of strategic planning, risk assessment, contracting, and performance management.

Behavioral Competencies

Strategic thinker capable of shaping long‑term vision and driving enterprise‑level transformation.Exceptional enterprise and matrix leadership, negotiation, and relationship‑building skills.Highly collaborative, with the ability to influence senior stakeholders and navigate matrixed environments.Strong communication skills and the ability to translate complex scientific and business concepts for diverse audiences.Demonstrated ability to manage multiple high‑stakes initiatives simultaneously and guide teams through ambiguity.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$212,000.00 - $333,190.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Objective / Purpose:

Takeda’s Lead Profiling team is building a new team of experienced, innovative, and collaborative researchers to partner with Drug Discovery Units to design and run high throughput automated assays on state-of-the-art robotic platforms to drive an industry-leading portfolio of drugs for various Therapeutic areas with high unmet medical needs. We are seeking a skilled research Senior Scientist to join our Lead Profiling and cross-functional discovery teams.

Design and execute pre-clinical pharmacology assays on fully automated robotic platforms to support candidate selection, accelerating clinical translation of impactful therapies for patients with various disordersProvide deep scientific expertise in the design and execution of miniaturized, high throughput assays to support programs across cross-functional teamsLeverage state-of-the-art automation to streamline complex biology screening workflows and manage data across various programs, in close collaboration with Takeda scientists and external partners

Accountabilities:                                                                                                  

Lead the design, development, and validation of robust plate-based miniaturized (384 and 1536-well) biochemical assays (e.g., enzyme, binding, target engagement assays) to facilitate compound screening, characterization, and mechanistic profiling to support medicinal chemistry SAR efforts.Develop and implement fully automated screening workflows to support multiple programs in the discovery portfolioChampion scientific integrity and rigor in data analysis, preparation, and interpretation of detailed protocols/SOPs.Lead the adoption of advanced analytics, modeling, and AI/ML approaches to inform assay design, hit triage, SAR development, and portfolio decisions. Contribute to the establishment of data standards and governance for biochemical lead profiling, enabling longitudinal data mining and cross-program learningCollaborate effectively within a matrixed structure, clearly communicate results, challenges, and impact through presentations and discussions with broad audiences.  Integrate data from cross-functional teams to drive decision-making.Think independently and creatively to explore novel drug discovery approaches to create therapies for patients suffering from disorders being investigated within Takeda discovery research.Maintain awareness of current developments in literature and contribute to the continuous process to enhance functional capability and productivitySupport the organization by maintaining a work environment focused on scientific integrity, continuous learning, open communication, and collaborationMentorship and coaching of other scientists within the team to create and sustain a high-performing team

Education & Competencies (Technical and Behavioral):

Expected: PhD degree in Biochemistry, Biophysics, Pharmacology, Molecular/Cell Biology or related field with 2+ years industry experience, or MS with 8+ years’ experience, or BS with 10+ years of relevant experience in pharmaceutical/ biotech R&D.Strong expertise, in-depth knowledge and hands-on experience in the development and optimization of a wide range of assays and screening technologies (e.g., Fluorecence, AlphaLISA, TR-FRET, ELISA, target engagement, residence time measurements etc).Working knowledge of HTS automation, liquid handling systems and assay miniaturization to streamline workflowsStrong expertise is Lead ID, Hit-to-Lead and Lead Op strategies and workflows is highly desirableSignificant experience leveraging high throughput data analysis platforms and LIMS systems for automated data analysis, QC and reportingStrong enzymology background preferredProven experience in developing and/or evaluating novel small molecule and biologicsStays current with emerging scientific literature, competitive landscapes, and innovative technologies to contribute to the continuous process to enhance functional capability and productivityAbility to collaborate in a multidisciplinary and dynamic environment, and experience in mentoring and leading other scientific staff

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$137,000.00 - $215,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Are you looking for a patient-focused, innovation-driven company to inspire you and empower you to shine? Join us as a Lead Clinical Study Manager based remotely reporting to the Clinical Operations Leadership team.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to work towards their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, and work toward excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to provide Better Health and a Brighter Future to people around the world.

Here, you will be a necessary contributor to our inspiring, bold mission.

GOALS:

Lead study operational strategy and planning and oversee execution of clinical studies for an assigned clinical program(s), supporting clinical strategy defined in Clinical Development Plan. In close collaboration with Clinical Operations Program Lead(s):

Oversee the execution of studies in assigned clinical program(s) in compliance with quality standards (including ICH GCP, local regulations and Takeda SOPs), on schedule and on budget.Oversee Strategic Partners and/or other CROs and other 3rd party vendors to meet Takeda’s obligations described in ICH-GCP and Takeda’s business objectives.

The assigned clinical studies may be high complexity and/or high risk, e.g. multiple indications, data safety monitoring boards and/or endpoint review committees, interim analyses, requiring the coordination of multiple vendors, or other special assessments. More than one study and/or more than one program may be assigned.

ACCOUNTABILITIES:

Accountable for planning and operational strategy and execution for assigned clinical trials.Provides subject matter expertise and operational input into protocol synopsis, final protocol and other study related documents.Challenges study team to ensure operational feasibility, inclusive of patient and site burdenValidates budget and ensures impacts are adequately addressed.Participates in country and site feasibility/selection process, with a focus on providing country insights, corporate alignment and therapeutic expertise to ensure alignment between study execution plan and program strategy.Challenges study team to ensure timelines meet the needs of the clinical development plan.Ensure new team members and vendors are appropriately onboarded.During Early Engagement with Strategic Partner(s) and/or other CROs, lead the development of the Operational Strategy in preparation for Operational Strategy Review; focus on ensuring accurate assumptions are applied and robust risk management plans are in place.Provide oversight/support/guidance to Strategic partners/CRO to ensure study issues are addressed and resolved rapidly.Responsible for study budget planning and management and accountable for external spend related to study execution.  Works closely with Clinical Operations Program Leader(s), Global Program Management, and Finance to ensure on a regular basis that budgets, enrollment, and gaiting are accurate; Communicates study status, cost and issues to Clinical Operations Program Lead(s); serve as escalation point for third party vendors managed by Strategic Partner and/or other CROs.Oversee Strategic Partners/CRO/vendor selection, budget and contract negotiation, and proper supervision of performance for all activities assigned to a Strategic Partner/CRO/vendor for assigned studies, including escalation of issues to governance committees when warranted.Specific areas of sponsor oversight include, but are not limited to:Review and approval of key monitoring documents/plans, periodic review of outputs, decisions and actions related to monitoringReview and endorsement of relevant study plans, as applicableStudy team meeting management and attendance when necessary; regular review of meeting agendas and minutesReview of outcomes/actions related to protocol deviations review; primary purpose of review is to support the identification of trends across sites and/or the studyDocumented review and monitoring of issues, risks and decisions at the study level and implementation of appropriate mitigation strategiesIn partnership with data management, review and pressure test all database timelines and plans; ensure strong linkage between the strategy (i.e., filing/registration, data generation, etc.) with the tactical plan for database lock and CSR.Ensure studies are “inspection ready” at all time; may be involved in regulatory inspections by preparing for and/or attending the inspections.Represent the Lead Clinical Study Manager role in functional initiatives or working groups. Help with onboarding and mentoring of new or junior CSMs.May assist the program COPL in his/her role, as required

EDUCATION AND EXPERIENCE:

BS/BA required preferably in a health-related, life science area or technology-related fields or equivalent combination of education, training and experience.Advanced degree(s) (e.g., Master or Doctorate) and relevant training or experience (e.g., fellowship. internships, etc.) may be considered to supplement experience requirements.6+ years’ experience in pharmaceutical industry and/or clinical research organization, including 4+ years clinical study management/oversight. Experience must include either early phase clinical studies or Phase 2 and 3 studies and global/international studies or programs. Experience in more than one therapeutic area is advantageous.Knowledge in global regulatory and compliance requirements for clinical research, including but not limited to US CFR, EU CTD, and ICH GCP. Awareness of local country requirements is also required.Demonstrated excellence in project/program management and matrix leadership.Excellent communication skills.Excellent teamwork, organizational, interpersonal, and problem-solving skills.Fluent business English (oral and written).

TRAVEL REQUIREMENTS:

Requires approximately 5-20 % travel, including overnight and international travel to other Takeda sites, strategic partners, and therapeutic area required travel.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Massachusetts - Virtual

U.S. Base Salary Range:

$116,000.00 - $182,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsMassachusetts - Virtual

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

#LI-Remote

Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

About the Role:

At Takeda, we are guided by our purpose of Better Health for People, Brighter Future for the World and our commitment to patients, our people, and the planet. Leading smooth transitions and integration of labs, systems, processes, and capabilities is essential to maintaining operational continuity and delivering on our commitments to patients, regulators, and partners.

We are seeking an Executive Director, Head of Lab Operations to lead and scale global laboratory operations across Takeda’s R&D organization. This role is responsible for ensuring that lab environments, processes, and systems are optimized to enable scientific excellence, operational efficiency, and scalability across a complex global footprint.

You will operate at the intersection of science, operations, and strategy—driving large-scale operational excellence initiatives, enabling scientists to focus on discovery, and shaping the future of laboratory operations, including preparation for the One Cambridge Campus.

What You Will Do:

As a key leader in the R&D Operational Excellence organization, you will:

Lead and oversee global R&D laboratory operations, defining standardized processes, roles, and governance while enabling best practice sharing across regions and appropriate local adaptation.

Develop and execute enterprise laboratory operations strategies to centrally scale and optimize services across R&D, increasing productivity and reducing administrative burden on scientific teams.

Ensure end-to-end operational support for R&D laboratories, including equipment, space, utilities, purchasing, maintenance, calibration, and materials flow, enabling scientific teams to focus on technical execution.

Drive R&D laboratory space and capacity strategy, including long term planning and readiness for the One Cambridge Campus, lab footprint scaling, asset utilization, storage, and materials flow optimization.

Coordinate global laboratory operations services and partnerships, serving as a primary interface for vendors and lab users; oversee CAPEX and OPEX, performance metrics, and continuous improvement, including innovation in automation, robotics, AI/data integration, and asset sharing.

Serve as the central R&D point of accountability for lab operations, including safety/EHS, procurement, and compliance, with clear escalation and issue resolution mechanisms to protect program timelines and support R&D simplicity goals.

What Makes This Role Unique:

This role sits at the center of enabling scientific innovation by ensuring that laboratory environments operate efficiently, consistently, and at scale across a complex global footprint. You will:

Lead high-visibility, enterprise-critical initiatives that shape the future of Takeda’s R&D laboratory operations.

Drive large-scale transformation in preparation for the One Cambridge Campus and evolving global lab strategy.

Balance the needs of scientists with operational efficiency, enabling productivity while simplifying processes.

Serve as a key partner across R&D and with external vendors, influencing how laboratory operations evolve globally.

Success in this role requires a leader who can balance strategic vision with operational execution and people leadership, while influencing across a highly matrixed, global organization.

What You Bring:

Deep experience in pharmaceutical R&D environments, including strong understanding of laboratory operations and processes.

Proven experience leading large-scale lab operations, including equipment, facilities, procurement, maintenance, and vendor management.

Strong experience driving operational efficiency, process improvement, and implementation of new systems.

Experience managing large-scale financial oversight, including CAPEX and OPEX budgets.

Strong understanding of safety, compliance, and regulatory considerations within laboratory environments.

Ability to think strategically while operating at a practical, execution-focused level, even in ambiguous situations.

Leadership & Impact:

Demonstrated ability to lead complex global organizations and drive operational and cultural change, both directly and through influence.

Strong leadership presence with the ability to influence, align, and inspire across functions, regions, and levels.

Proven ability to lead transformation initiatives, implement new systems, and drive process changes.

Ability to establish alignment through collaboration and persuasive communication; strong communicator with excellent written, verbal, and presentation skills.

Ability to influence and work effectively across business partnerships, regions, and cultures while balancing scientific needs with operational efficiencies.

Education & Experience:

Bachelor’s degree in life sciences, pharmacy, engineering, operations, business management, or related field.

15+ years of experience in pharmaceutical R&D, with a preference for lab operations management & leadership, and deep experience working with scientists, vendor management and procurement functions in an R&D lab environment.

Minimum 7 years of people leadership experience, including driving process change and implementing systems.

Experience working within complex, matrixed organizations across functions and regions.

Proven track record of leading large-scale lab operations, driving organizational change, and delivering complex programs.

Preferred:

Advanced degree in science or business.

Certifications in operational excellence, vendor management, or process improvement programs.

Additional Information:

Requires approximately 10–15% travel, including domestic and international travel.

Flexibility to support meetings across global time zones.

This position is currently classified as “hybrid” in accordance with Takeda’s Hybrid and Remote Work policy.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$238,000.00 - $374,000.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

Objective / Purpose:

Takeda’s Lead Profiling team is building a new team of experienced, innovative, and collaborative researchers to partner with Drug Discovery Units to design and run high throughput automated assays on state-of-the-art robotic platforms to drive an industry-leading portfolio of drugs for various Therapeutic areas with high unmet medical needs. We are seeking a skilled Associate Scientist to join our Lead Profiling and cross-functional discovery teams.

Design and execute pre-clinical pharmacology assays on fully automated robotic platforms to support candidate selection, accelerating clinical translation of impactful therapies for patients with various disordersProvide hands-on expertise in the design and execution of miniaturized, high throughput assays to support programs across cross-functional teamsLeverage state-of-the-art automation to streamline complex assay workflows and generate data to support various programs, in close collaboration with Takeda scientists and external partnersCollaborate with multi-disciplinary team of drug discovery scientists that include Medicinal/Discovery Chemistry, Biology and Data Science to advance multiple small molecule programs as new clinical candidates for the treatment of various diseases.Design, optimize and execute biochemical screening assays including data analysis and interpretation.Optimize assays to support high throughput screening (HTS) and participate in screening hit validation and profiling using orthogonal biochemical assays.Ensure the timely execution of both HTS and IC50 determinations of profiling assays, and timely delivery of DMTA data to program teams.Interpret, summarize, and present research findings in internal working group meetingsMaintain a stable and productive environment through Quality Control (QC), preventative maintenance (PM), and standard operating procedures (SOP).Demonstrate working knowledge of HTS automation platforms and associated assay technologies for lead-finding and follow-up activities.Demonstrate experience and understanding of HTS data analysis and software packages.

Education & Competencies (Technical and Behavioral):

Expected: Master’s degree in Biochemistry, Cell Biology, Molecular Biology or related discipline with 3+ years OR Bachelor’s degree with 5+ years of relevant industry experience.Design and development of biochemical 384 and 1536-well plate-based assays (e.g., fluorescence, HTRF, FRET, bioluminescence assays, BRET etc.)Prior experience in small-molecule screening that includes familiarity with liquid handlers and automation systems is highly desirableProficiency in HTS automation is a plusDemonstrated ability to work independently and collaboratively to advance drug discovery projects in a highly matrixed environmentOutstanding organizational skills and attention to detailExcellent cross-functional collaboration, communication, and interpersonal skills

Enzymology background preferred

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA. 

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$103,500.00 - $162,690.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Pursuant to Section 20 C.F.R. 656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas, Inc. for the following job opportunity:

JOB LOCATION: Cambridge, MA

POSITION: Senior Data Scientist

POSITION DESCRIPTION: Takeda Development Center Americas, Inc. is seeking a Senior Data Scientist with the following duties: collaborate with a diverse set of users and partners across multiple functions to translate unstructured, complex business problems into appropriate data, modelling and analytical solutions; lead data science projects through the data, analytics & machine learning lifecycle; clearly and objectively communicate results, as well as their associated limitations; apply and maintain methods, techniques and developments in analytics and data science; mentor and support other data scientists across multiple projects to drive the development of data science as a capability; develop and review working practices to ensure that data science work is delivered to robust quality standards. Up to 25% domestic travel required for hybrid requirements for onsite meetings and department events. Up to 75% remote work allowed.

The estimated salary range reflects an anticipated range for this position. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

REQUIREMENTS: Master’s degree in Data Science, Analytics, Business Analytics, Computer Science, Engineering, or related field plus 4 years of related experience. Prior experience must include: 4 years of data and analytics experience in life science, pharma, biotech, technology companies or relevant regulated industries; collaborate with cross-functional teams to understand business requirements and translate them into analytical solutions; perform end-to-end data processing including extraction, cleaning, transformation, and analysis using SQL queries across multiple database systems; develop advanced analytical solutions leveraging Python, R, and other programming languages to support data-driven decision making; implement version control practices using Git to manage code repositories and leverage cloud computing infrastructure like AWS; design and implement data visualization solutions using tools like Tableau, Power BI, or similar platforms and enable self-service analytics; present data-driven insights and recommendations to senior leadership and key stakeholders.

Full time. $162,000 to $260,000 per year.

Qualified applicants can apply at https://jobs.takeda.com. Please reference job #R0176617. EOE

Any individual may provide documentary evidence bearing on this application, with information on available workers and information on wages and working conditions, to the Certifying Officer, U.S. Department of Labor, Employment and Training Administration, Office of Foreign Labor Certification, 200 Constitution Avenue, NW, Room N-5311, Washington, DC 20210.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Objective / Purpose:  

The Director, Target Validation Sciences will lead a next-generation, automation-enabled assay hub for human disease–relevant target validation. Working closely with the Lab of Tomorrow (Takeda’s lab automation and digitalization initiative), this role will transform how target validation is conducted by integrating advanced 3D disease models, organ-on-a-chip technologies, automation, and AI-enabled data analytics into scalable, decision-driving platforms. 

This role will contribute to and help shape the scientific direction of target validation across therapeutic areas, modernize workflows through digitalization, and support assay transfer across functions while driving the standardization and centralization of assay platforms, accelerating portfolio progression. 

Accountabilities:  

Establish and grow a center of excellence for human disease–relevant assay platforms, integrating advanced 3D tissue culture systems, organ-on-chip technologies, and automation-enabled approaches to support scalable target validation. Own and drive cross-functional assay transfer and standardized workflows (including SOP frameworks), partnering with platform teams to ensure reproducibility, scalability, and data quality across target validation platforms. Provide scientific and strategic leadership in target validation for GI inflammatory/fibrotic diseases, oncology, and Neuroscience, including development of novel, disease-relevant assays that translate mechanistic biology into decision-driving data and enable pipeline progression. Partner closely with the Lab of Tomorrow, as well as Computer Science and Data Science teams, to integrate automation-enabled workflows, AI-driven analytics, and computational approaches into scalable target validation platforms. Align target validation strategies with portfolio priorities across Boston and Shonan sites, contributing to TVS leadership discussions and establishing best practices. Influence target progression through rigorous data interpretation and sound scientific judgment. Build and develop a high-performing scientific team while ensuring quality and compliance standards supporting IND-enabling activities where applicable. 

Education & Competencies:  

PhD required in Immunology, Molecular/Cell Biology, Pharmacology, or related discipline with 6+ years of biopharmaceutical industry experience. Strong expertise in GI inflammatory and fibrotic biology (including IBD) and/or oncology. Demonstrated success in mechanism-based target validation and human disease–relevant assay development (e.g., 3D tissue culture systems, complex cellular models). Deep experience leading cell-based assay development for scalable target validation platforms, including assay design at the appropriate well scale and optimization for robustness, reproducibility, and transferability to automated environments. Experience partnering with Computer Science and Data Science teams and leveraging AI-enabled analytics to inform biological decision-making. Proven people leadership and cross-functional influence in a matrix environment. Strategic thinker with strong scientific judgment and communication skills. 

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$177,000.00 - $278,080.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Title: Research Scientist, AI/ML – Agentic Systems

Position Overview

We are seeking a Research Scientist to develop agentic AI systems that transform how drug discovery research is conducted. As part of the AI/ML Foundation team, you will build autonomous AI agents capable of reasoning, planning, and executing complex scientific workflows—from literature synthesis and target identification to experimental design and data analysis. This role requires a unique combination of expertise in large language models, agentic frameworks, and understanding of drug discovery processes. You will translate standard research workflows into agentic frameworks, develop new agent skills, and deploy systems that augment scientist productivity across Computational Sciences and Global Research.

Key Responsibilities

Develop agentic AI systems for drug discovery applications including target-disease association, automated literature search and synthesis, hypothesis generation, and intelligent design of experiments.Translate standard research workflows into agentic frameworks—decomposing complex scientific processes into autonomous agent tasks that can reason, plan, execute tools, and iterate based on results.Design and implement new agent skills (tools, functions, APIs) that extend agentic capabilities to specialized scientific domains including molecular design, property prediction, assay planning, and data analysis.Build agentic systems that integrate with foundation models and external knowledge sources for autonomous hypothesis generation, evidence retrieval, and scientific reasoning.Develop retrieval-augmented generation (RAG) pipelines connecting agents to internal and external scientific literature, databases, and experimental results.Partner with research scientists to understand workflow needs, validate agent outputs, and iterate on system design to ensure scientific rigor and utility.Stay current with advances in agentic AI, LLM applications, and scientific automation; contribute to internal knowledge sharing and external publications.

Qualifications

Required:

PhD in Computer Science, Computational Biology, Bioinformatics, or related fieldExperience with large language models (GPT, Claude, Llama) and their application to complex reasoning tasks.Proficiency in Python and experience with agentic AI frameworks (LangChain, AutoGen, CrewAI, or similar).Experience building RAG systems including vector databases, embedding models, and retrieval pipelines.Understanding of drug discovery processes and scientific research workflows.Strong problem-solving skills and ability to translate complex scientific processes into computational workflows.

Preferred:

Experience in pharmaceutical or biotech R&D environments.Background in biology, chemistry, or disease biology.Experience with reinforcement learning or planning algorithms for agent decision-making.Familiarity with scientific databases (PubMed, UniProt, ChEMBL) and APIs.Experience deploying AI systems in production environments.Track record of publications or presentations on LLM ap

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA.  This position is currently classified as “hybrid” by Takeda’s Hybrid Work policy

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$116,000.00 - $182,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time Type

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Read Less

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.  I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Pursuant to Section 20 C.F.R. 656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas, Inc. for the following job opportunity:

JOB LOCATION: Cambridge, MA

POSITION: Research Senior Associate

POSITION DESCRIPTION: Takeda Development Center Americas, Inc. is seeking a Research Senior Associate with the following duties: design and execute in vitro antibody discovery campaigns using yeast and phage display techniques. Independently conduct complex experiments, and implement display technologies to discover and advance novel biotherapeutic products through discovery and optimization stages. Generate diverse repertoires from immunized animals to build immune libraries for discovery purposes. Design and build maturation libraries for display platforms (affinity/potency/ stability), leveraging datasets and software to improve lead candidates. Prepare samples for sequencing by NGS or Sanger methodologies, including data analysis. Perform mammalian cell culture, ELISA and flow cytometry experiments, including sorting by utilizing BD Canto, ARIA and HT systems. Develop and use molecular cloning strategies for antibody gene amplification, library construction, and for generating antibody diversities for display libraries. Complete molecular biology techniques including DNA and RNA extraction, PCR, RT-PCR, restriction enzyme digestions and site directed mutagenesis. Exercise technical judgement in execution of specialized procedures and interpretation of results. Initiate routine problem investigation and recommend solutions; perform calculations and basic analysis on experimental results and develop hypotheses. Contribute to design of well-defined experimental procedures; maintain responsibility for routine laboratory instrumentation and supplies; track, collect, organize and analyze data from matrix teams; required to track data from LIMS systems and maintain detailed electronic notebook. Up to 20% remote work allowed.

The estimated salary range reflects an anticipated range for this position. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

REQUIREMENTS: Master’s degree in Biochemistry, Biotechnology, Molecular. Biology, Immunology Bioengineering, or related field, plus 1 year of related experience. Prior experience must include: design antibody discovery phage campaigns and strategize selections arms for given targets; build immune/single domain phage libraries using molecular biology techniques; independently handle and lead projects from discovery to clone selection for target discovery campaigns; design recombinant plasmids to generate overexpressing/knock-out cell-lines using molecular biology; develop high-throughput cell-based flow cytometry assays to screen potential antibody candidates to increase screening efficiency; laboratory experience in yeast and/or phage display, antibody discovery, molecular biology or related research role.

Full time. $86,500 - $148,300 per year.

Qualified applicants can apply at https://jobs.takeda.com. Please reference job #R0175792. EOE

Any individual may provide documentary evidence bearing on this application, with information on available workers and information on wages and working conditions, to the Certifying Officer, U.S. Department of Labor, Employment and Training Administration, Office of Foreign Labor Certification, 200 Constitution Avenue, NW, Room N-5311, Washington, DC 20210.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time Read Less