GENERAL DESCRIPTION:
Precigen is a dedicated discovery and clinical stage biopharmaceutical company advancing the next generation of gene and cell therapies using precision technology to target the most urgent and intractable diseases in our core therapeutic areas of immuno-oncology, autoimmune disorders, and infectious diseases.
Precigen has developed novel manufacturing processes to deliver UltraCAR-T® and AdenoVerse™ immunotherapies to patients. We have multiple products being evaluated in the clinic using our innovative manufacturing approach to cell and gene therapies.
Research Associate– Process Development Upstream requires a professional who thrives in a dynamic team environment, brings meticulous attention to detail in the quality of their work and is proactive in implementing improvements. This position will be supporting all Gene Therapy CMC aspects of early stage to commercialization of adenovector products.
EDUCATION AND EXPERIENCE:
BS in chemical/biochemical engineering, Biotechnology or related discipline with 2-3 years of relevant industrial experience in upstream process development; or M.S. degree in a similar field with 1-2 years of relevant experience in upstream process development.Strong computer skills with Microsoft Office and the ability to quickly learn new applications.Experience in summarizing and presenting data and authoring technical reports.DUTIES AND RESPONSIBILITIES:
Perform hands-on work in upstream process development to execute cell culture using shake flasks and bench scale bioreactorsMaintain and coordinate raw material and equipment inventories; ensure equipment is operated and maintained in a safe, compliant manner.Keep accurate, detailed laboratory records; comply with all required training and maintain a strong focus on laboratory/facility safety for self and team members.Author process development protocols, procedures, and development reports.Communicate and present scientific findings in process development groups.Required Experience and Skills
Sound aseptic cell culture technique, including working in Biosafety Cabinets (BSC).Proven written and verbal communication skillsCritical thinking with ability to work in a dynamic and fast-paced team environmentSelf-organizer, meticulous hands-on habits, keen attention to detail.Hands on laboratory skills to conduct bench work to execute, optimize, and troubleshoot cell culture processes (e.g., shake flasks, bench scale and pilot scale bioreactors).Experience with data analysis, interpret datasets, and support process understanding and optimization.Ensuring compliance with regulatory guidelines and quality standards throughout all stages of process development and manufacturing.Maintain a high degree of ethical standard and trustworthiness.Working conditions and physical requirements:
May need to work with infectious agents and hazardous chemicals.Able to stand up to 4 hours at a time. Read LessGENERAL DESCRIPTION:
We are seeking a proficient Senior Data Scientist within Precigen’s Bioinformatics team who will be responsible for sequence data analysis, statistical analysis, and data mining. This individual will maintain and develop analysis pipelines, run data analyses, visualize results and communicate them to lab scientists and principal investigators. Extensive experience with DNA and RNA sequencing analysis and strong knowledge of statistical methods, coupled with a solid understanding of foundational biological principles, will be required. You will join a transnational team working at the intersection of biology, data science, and software development.
DUTIES AND RESPONSIBILITIES:
Perform computational analysis of DNA and RNA sequences.Perform statistical analyses on experimental data from molecular and cell biology, immunology and oncology.Mine clinical data with machine learning methods.Perform computational analysis of protein sequence data.Visualize and communicate analysis results to biologists.Contribute to scientific writing.EDUCATION AND EXPERIENCE:
PhD, MS, or equivalent experience in molecular biology, biochemistry, computational biology, bioinformatics or a related discipline.Five or more years of experience with computational DNA analysis (insertion analysis, variant analysis), bulk and single cell RNA analysis, expression analysis, and pathway analysis.Familiarity with bioinformatics concepts and standard tools for sequence data handling, sequence alignment, and differential expression analysis.Good knowledge of statistics.Familiarity with the Unix/Linux command line.Strong programming skills in R and Perl.Extensive experience with data analysis and visualization.Knowledge of and experience with machine learning concepts and methods.Experience with protein sequence analysis from mass spectrometry data.Familiarity with AI-based tools is appreciated.
DESIRED KEY COMPETENCIES:
Capable of adapting to rapidly changing and developing requirements.The candidate can engage effectively with scientists to understand the design, rationale, and scientific context of lab experiments, ensuring that data analyses align with experimental goals.They can clearly communicate the methods, reasoning, results, and interpretations of their analyses within the Bioinformatics team and across research groups.Ready to seek, accept, and provide feedback and advice from and to team colleagues and management.Communicates issues and problems openly and early.Exhibits high performance both independently and in a team setting.Delivers work on schedule and within agreed timeframes.Is comfortable with communicating predominantly via electronic means.Effectively conveys information in a clear, structured manner.Can interact proficiently in an international and culturally diverse environment where not everyone is a native speaker of English.Sufficient language skills in German to discuss professional matters are a plus.EOE MFDV
