About Oxford Biotherapeutics:
Oxford Biotherapeutics is a clinical-stage biotechnology company focusing on the development of antibody therapeutics for the treatment of cancer.OBTsOGAP-verify platform is the world's largest, cancer specific, membrane protein library, directly measuring plasma membrane protein expression in patienttumors. OGAP is used to identifynovel, highlytumorspecific antigens for novel first-in-class ADC, T-cell Engager (TCE)and Chimeric Antigen Receptor (CAR-T) targets. Our lead asset, OBT076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development. Our clinical and pre-clinical pipeline of novel biologics is balanced between internal programs, focused on ADCs and checkpoint regulators, and externally partnered programs with key innovators in oncology such asRoche,GSKand Zymeworks.
Job Description
We areseekinga highly motivated and intellectually curious T-Cell Biologist to join our discovery research organization. This individual will playa central rolein advancingT-cellengagers by generating high
quality, decision
driving data from early discovery through IND. The role blends hands
on experimentalexpertisewith scientific leadership, assay innovation, and cross
functional collaboration.
Depending on experience, this role may be filled at theScientist orSenior Scientist level.
Responsibilities will include, but are not limited to, the following:
Scientific Leadership & Program Execution
Design, execute, and lead in vitro functional studies supporting target discovery, validation, lead selectionand optimization, and preclinical development of Tcell engagers.Develop,optimize, andrunTcellfunctional assays to inform potency, selectivity, and safety.(e.g., cytotoxicity, cytokine release, activation, immune profiling, reporter assays).Design and runcocultureassays to evaluateTcellmediated tumor cell killing in response toTcellengagers.Design and executeprimary humanTcellassays, including activation,cytokine release,T-cell exhaustion,mixed lymphocyte reaction assays and proliferation. Generate and interpret complex datasets with a strong emphasis on scientific rigor, reproducibility, and data quality.Builddecision-focuseddata packages and communicate clear scientific conclusions and recommendations to project teams, management, and external collaborators.Assay Development & Technical Expertise
Develop and execute multiparameter flow cytometry, includingactivationand intracellular cytokine staining.Design and performreal-timecytotoxicity assays (e.g., IncuCyte, eSight) and other functional readouts relevant to Tcell engager activity.CharacterizeTcellengagers usingcellbasedfunctional assays, including cytokine release and cytotoxicity.UnderstandvariousTCE formatsandimprove tumor-specific killing efficacy.Collaboration &CrossFunctionalEngagement
Collaborate closelyacrossteams toevaluateandoptimizeT-cell engager molecules.Coordinate with external collaborators and CROs to deliver high quality, timely data.Proactivelyidentifyproject risks, propose mitigation strategies, and communicate progress and challenges clearly to stakeholders.Innovation & External Awareness
Monitor the scientific literature and competitive landscape relevant toT-cell engagers and emerging immuneredirecting modalities.Propose innovative experimental approaches to accelerate early-stagediscovery.Serve as an internal subjectmatter expert inTcellimmunobiology and immune redirecting therapies.Monitor the scientific literature and competitive landscaperelevant to OGAP-selected targets.Team Leadership & Culture
Foster a culture of scientific rigor, learning, transparency, accountability, and inclusion.Act as a scientific thought leader within the research organization.Compliance & Documentation
Adhere to OBTs Quality Management System (QMS), including SOPs, documentation standards, electronic lab notebooks, and required training.Support audit readiness and contribute to continuous improvement of laboratory systems and workflows.Required Qualifications and Skills:
Deep expertise in Tcell immunobiology, with handson experience working with Tcell engagers and/or bispecific antibody formats.Strong hands-on experience with core immunology techniques, including:PBMC and primary human T-cell isolation, culture, and functional assaysMultiparameter flow cytometry and panel designIntracellular cytokine staining & other flow-based assaysCell-based reporter assaysDemonstrated ability to design, analyze, and interpret complex datasets and translate results into clear scientific conclusions.Strong written and verbal communication skills, with the ability to present data to multidisciplinary audiences.Combines a humble, teamoriented mindset with the ability to form and voice clear, independent viewpoints.Scientist Level
PhD with 13 years of relevant postPhD experience, orMS with 57 years of relevant industry experience in immunology, cell biology, or biologics discoverySenior Scientist Level
PhD with 46 years of relevant postPhD experience, orMS with 812 years of relevant industry experience demonstrating increasing scientific independence and technical leadershipPreferred Qualifications and Skills:
Experience contributing to biologics discovery programs from early discovery through lead optimization and/or preclinical development.Track record of scientific impact demonstrated through publications, patents, presentations, or program advancement.Experience with both traditional and homogeneous ELISAderived platforms, including AlphaLISA and/or multiplex systems such as Luminex.Oneofourtopprioritiesistomaintainthehealthandwellbeingofouremployeesandtheirfamilies.Toachievethisgoal,weoffercomprehensivebenefits.
BenefitsOffered:
Medical,dentalandvisioninsuranceforemployeeanddependentsFSA(FlexibleSpendingAccount)STD,LTD,BasicLifeandAD&DInsurance,SupplementalLife401(k)Plan120hoursofPaidTimeOff5sickdaysperyear11holidaysEmployeeReferralBonusProgramAnnualbonusprogramNewhirestockoptionsEqualOpportunitiesStatement
OBT is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will receive consideration for employment. One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits
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