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Alnylam Pharmaceuticals
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  • Senior Process Engineer  

    - Middlesex County
    Overview The Senior Process Engineer will support R ability to react q... Read More
    Overview The Senior Process Engineer will support R ability to react quickly to understand and solve problems Strong understanding of GMPs and good engineering practice (GEP), including industry standards and guidelines, such as, ASME BPE, ISPE Baseline Guides, CFR's, OSHA, ISA S88, GAMP, ASTM E2500, etc. #LI-LJ1 #LI-Onsite U.S. Pay Range $129,000.00 - $174,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • Overview We are seeking an associate scientist-II to join our protein... Read More
    Overview We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein expression, purification, protein conjugation and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment.The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities This lab-based position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142 Key Responsibilities Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales. Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members. Utilize UV-Vis spectroscopy and HPLC to analyze, purify, quantify, characterize, and formulate protein conjugates. Contribute to the maintenance of laboratory infrastructure and equipment. Support group organization, productivity, and expertise through collaboration and idea exchange. Meet quality, quantity, and timeline expectations for all assigned projects. Support discovery efforts in protein sciences. Maintain accurate and complete electronic notebook records. Communicate experimental plans and data to multiple cross-functional scientific teams. Qualifications BS/MS degree in biology, biochemistry, biophysics, chemistry, or a related field, with 0-1 years of relevant laboratory experience in a biopharma or academic setting. Experience with modern bioconjugation chemistry and analytical techniques. Experience with instrumentation such as Agilent and AKTA HPLC systems, TFF, and UV-Vis spectrometry. Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV-Vis spectroscopy) and label-free binding techniques (SPR and/or BLI) preferred. Experience developing new chromatographic methods is a plus. Knowledge of protein purification using AKTA systems preferred Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems. Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting. Effective written and oral communication skills. #LI-JR1 U.S. Pay Range $67,600.00 - $101,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • VP, US TTR Marketing  

    - Middlesex County
    Overview The VP, Head of US TTR Marketing, is a highly visible, missio... Read More
    Overview The VP, Head of US TTR Marketing, is a highly visible, mission-critical role that will report to the SVP, US Head of Business and will be a core member of the US Leadership Team. This person will be pivotal in defining the goals, strategies, tactics, and metrics necessary for maximizing the potential of Alnylam's US TTR franchise. The VP will lead a team of 20-30 marketers and thought leader liaisons (TLLs), fostering a culture of customer-centricity, thoughtful risk-taking, and cross-functional partnership. This person's leadership will be instrumental in maximizing Alnylam's competitiveness, navigating the complexities of the biopharmaceutical landscape, building and cultivating strong relationships with key stakeholders, and enhancing patient access to our life-preserving therapies. A key element of this person's success will be building a culture of deep collaboration across the breadth of Alnylam's functions including Sales, Account Management, Medical Affairs, Market Access, Patient Services, Legal, and Compliance. This is a virtual position but will require regular travel to Alnylam's headquarters in Cambridge, MA. Key Responsibilities Strategic Planning: Develop and implement comprehensive marketing strategies for driving awareness and diagnosis of TTR amyloidosis, and for maintaining high preference/market share of Amvuttra and Onpattro among HCPs and patients. Team Leadership: Lead, mentor, and develop a multidisciplinary marketing team, fostering a culture of customer-centricity, thoughtful risk-taking, and cross-functional partnership. Ensure alignment of goals, strategies, and tactics across the marketing team as well as the broader cross-functional team spanning Medical Affairs, Sales, Account Management, Market Access, Patient Services, Regulatory, and Legal. Brand Management: Oversee the development and execution of brand strategies, ensuring consistent messaging across all channels and touchpoints. Drive brand awareness, engagement, and loyalty among target audiences. Market Insights: Leverage market research and data analytics to gain insights into customer behaviors and market trends. Inform strategic decisions and optimize marketing campaigns to meet market needs effectively. Stakeholder Engagement: Cultivate strong relationships with key opinion leaders, patient advocacy groups, and professional organizations. Develop and support programs that enhance disease awareness and education. Regulatory Compliance: Ensure all marketing activities comply with regulatory guidelines and ethical standards. Work closely with legal and regulatory teams to navigate the approval process for marketing materials and campaigns. Performance Metrics: Establish and monitor key performance indicators to measure the effectiveness of marketing strategies. Adjust plans as necessary to achieve business objectives. Qualifications Bachelor's degree required, MBA or advanced degree in a related field preferred. ~15 years of US/global biopharma marketing and business experience, with experience managing sizable teams Proven track record of developing and executing successful marketing campaigns andstrategies in competitive markets for pharmaceutical products. Experience at large biopharma company preferred. New product launch experience is a must. Extensive experience with HCP and consumer marketing, as well as engagement with, and cultivation of, thought leaders. Experience in cardiology preferred. Deep understanding of the US healthcare system, reimbursement landscape, and regulatory environment. Strategic thinker with the ability to analyze complex data and market insights to drive decision-making. Strong leadership, communication, and collaboration skills. Excellent communication, negotiation, and interpersonal skills. Strong executive presence Demonstrated ability to lead and inspire a team towards achieving common goals. Demonstrated ability to foster and drive cross-functional collaboration. Possesses high integrity and exceptional work ethic. Willingness to travel as needed. #LI-Remote #LI-ST1 U.S. Pay Range $323,000.00 - $437,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • Overview The Strategic Account Lead (SAL) roleleads strategic engageme... Read More
    Overview The Strategic Account Lead (SAL) roleleads strategic engagement and contracting with target key accounts in order to drive growth, revenue, and joint value creation for Alnylam and the customer by enabling and optimizingaccess toAlnylam products and driving innovation for patients and health care providers. Key Responsibilities The Strategic Account Lead (SAL) will provide innovative, influential account engagement to shape and deliver the strategy for Alnylam Strategic Accounts in order to achieve access, create value and deliver profitable growth for Alnylam. Lead the development and execution of the comprehensive account strategy for target accounts to bring the best of Alnylam to the customer and to maximize profitability, revenue growth and market share for Alnylam Analyze and synthesize information from multiple sources to identify and prioritize business opportunities across the account by applying relevant frameworks and analytical methods Work with the Alnylam Leadership Team to co-develop and agree on strategies, programs objectives and KPIs for target regional accounts aligned with organizational and brand priorities and the wider business strategy Support the account team with the prioritization of solutions, programs and specific pull-through tactics to ensure sustainable growth and mutual value creation Anticipate likely market and customer developments, identify third party influence factors and shape the account strategy accordingly Partner with target healthcare systems and organized customers to foster innovation in care through the adoption of Alnylam's products Engage senior level stakeholders to influence policies, decisions and perceptions to enable patients to effectively navigate the treatment journey and ensure appropriate use of Alnylam products Facilitate the introduction of new products and indications with institutional stakeholders by ensuring adequate budget allocation at the strategic account level Leverage a range of strategies and tactics to maximize the level and quality of access for Alnylam products Identify programs to partner with the Organized Customer to enhance the system of care and clinical decision making Provide insights, education and information about scientific, clinical and technological innovation Facilitate strategic partnership with account stakeholders to create mutual value for Alnylam and customers and deliver strategic goals Identify and maintain strong relationships with senior business stakeholders (Chief, VP, Director) in target accounts to support access for Alnylam's products across the company portfolio Strengthen the perception of Alnylam as a strategic partner by sharing insights and information to support patient identification and improving the delivery of care by establishing treatment pathways and protocols Provide clear direction to other field teams to identify and prioritize stakeholders within their target accounts Negotiate, review and agree contracts, incorporating solutions to strengthen partnerships with strategic account stakeholders Collaborate with other functional and business leaders to ensure adequate Voice of the Customer to inform strategic planning across all stakeholders and channels Support the delivery of account goals for National accounts, working closely with the Strategic Accounts Team Support the execution and pull through of contracting and initiatives with national organized customers to ensure value maximization Measure, report and communicate value delivered for national organized customers in order to strengthen customer partnership Share insights gathered through customer engagement Qualifications Bachelor's degree, emphasis in Accounting, Marketing, Business Administration or equivalent work experience in business management, ideally complemented by an MBA Minimum 7 years of experience in B2B selling in a life sciences environment Previous account management experience with health systems and/or hospitals/ IDNs High level of confidence and capability to understand and communicate complex scientific concepts to a range of stakeholders, plus executive presence and communication skills to engage with a C-Suite audience Expertise and understanding of dynamic market access value models such as value-based propositions and budget impact and cost effectiveness models, etc Strong interpersonal skills including written and oral communication skills, ability to synthesize data, interpret and translate into compelling and clear commercial strategies and plans Demonstrated ability to successfully mobilize a cross-functional team, including interpersonal skills to foster collaboration and succeed in a highly matrixed environment by leading without direct authority Understanding of the IDN environment, including coverage and reimbursement, pricing and contracting, formulary management and health technology assessment Strong analytical skills and ability to think critically, challenge conclusions and underlying assumptions Ability to synthesize multi-source information (qualitative and quantitative) to develop strategic plans Knowledge of value based healthcare and outcome based models Executive presence and the ability to interact and negotiate with C-suite customers Highly proficient in Microsoft; Excel, Word, and PowerPoint Additional Preferred Experience Master's degree: Master of Business Administration (MBA) preferred Active membership of relevant pharmaceutical associations would be beneficial #LI-ST1 #LI-Remote U.S. Pay Range $204,000.00 - $276,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • Scientist, Research (Targeted Delivery)  

    - Middlesex County
    Overview The Research Department at Alnylam is seeking a Scientist to... Read More
    Overview The Research Department at Alnylam is seeking a Scientist to join a growing team responsible for advancing RNAi therapeutics into the future, by opening up targeted delivery to all tissues. The successful candidate will have a working knowledge of receptor biology and ligand/receptor characterization. This role requires hands-on expertise in tools and techniques used to identify receptors and characterize ligand-receptor interactions. The individual will need excellent collaboration and communication skills to work collaboratively across the research department. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities Contribute to an interdisciplinary team focused on expanding targeted delivery into new cell types and tissues. Design, optimize, and execute a wide range of analytical and biophysical assays to assess the identity, purity, stability, and aggregation propensity of ligand candidates. Analyze and interprete complex data from various techniques to guide the selection and engineering of ligand with optimal biophysical properties. Establish tools, techniques, and assays to identify and characterize new receptors to unlock targeted delivery into new cell types and tissues. Transparently communicate results with key stakeholders throughout the organization. Qualifications PhD in Biochemistry, Molecular Biology, Cell Biology, or related field. 0-3 years of experience in biopharma setting. Expertise in receptor biology and characterizing ligand/receptor interactions using ELISA, Western blot, FP, ITC, and BLI/SPR. Strong background in protein biophysics to characterize the ligand using DSF, DLS SEC. Excellent communication skills (both written and oral) are essential. Familiarity with high-throughput automation setup is preferred. #LI-JR1 U.S. Pay Range $110,400.00 - $165,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • Scientist, Antibody Engineering  

    - Middlesex County
    Overview: We are seeking a Scientist to join the Protein Sciences team... Read More
    Overview: We are seeking a Scientist to join the Protein Sciences team to design and validate antibody molecules for the targeted delivery of oligonucleotides. The candidate will work across teams to validate receptors, assist with antibody discovery campaigns, and advance lead molecules for conjugation. The candidate will bring expertise in antibody engineering and receptor validation. This position is onsite and will be primarily located in Cambridge, MA. Responsibilities: Design antibodies and antibody fragments across multiple formats (bispecifics, Fc fusions, Fabs, scFvs). Research tool antibody molecules for target validation and assist with antibody discovery campaigns for selected targets. Model antibody structures using relevant software like Pymol and ChimeraX. Characterize protein quality and stability using methods like SDS-PAGE, melting point, size-exclusion chromatography, ion exchange, UV-Vis, DLS, and ELISA. Work with CROs to produce antibodies and troubleshoot expression issues. Develop and perform binding assays using BLI (Octet) or SPR (Biacore) for epitope binning and determination of kinetic binding parameters. Meet quality, quantity, and timelines in all assigned projects. Proper electronic notebook record keeping. Contribute to a cross-functional team of biologists, chemists, and pharmacologists to drive the strategic direction of research programs across multiple therapeutic modalities. Qualifications: PhD degree with 1-2 years of relevant experience with a focus on antibody design and engineering. Deep understanding of antibody design, protein structure and protein purification across multiple formats including bispecifics, Fc fusions, Fabs, and scFvs. Strong technical background in antibody characterization includes binding kinetics and therapeutic applications for target mediated delivery. Experience with recombinant protein analysis for monoclonal antibodies (SDS-PAGE, size exclusion chromatography, reverse phase chromatography, hydrophobic interaction chromatography, ion exchange chromatography, and UV-VIS spectroscopy). Passionate about driving his or her projects from the bench to independently contribute to research directions and solve challenging issues. Detail oriented, self-motivated, and comfortable working with highly technical projects. Ability to work on multiple projects simultaneously and deliver conclusive results. Highly adaptable and responsive to new priorities in a fast-paced environment. Effective written and oral communication skills. Experience preparing and presenting using PowerPoint software. Team oriented with strong work ethic #LI-KB1 #LI-Onsite U.S. Pay Range $110,400.00 - $165,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • Overview We are looking for experienced Business Account Executives (B... Read More
    Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals. Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care. Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results. Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers. Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results. Demonstrates and upholds the highest standards of integrity and compliance. Additional responsibilities as required to support business needs and organizational priorities. Qualifications 4-year degree from an accredited college or university required. MBA/Science Degree preferred. 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry. Experience in Cardiology A successful track record of strong sales performance. Specialty product launch experience Understanding of buy and bill and specialty channel distribution is preferred. Hospital / Institution knowledge and expertise with pharmacy formulary processes. Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority. Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times. Excellent communication and listening skills. Collaboration: Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues. Customer Focus: Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge Execution: Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact. Critical Thinking: Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence. Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories. Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable. Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • Overview We are looking for experienced Business Account Executives (B... Read More
    Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals. Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care. Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results. Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers. Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results. Demonstrates and upholds the highest standards of integrity and compliance. Additional responsibilities as required to support business needs and organizational priorities. Qualifications 4-year degree from an accredited college or university required. MBA/Science Degree preferred. 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry. Experience in Cardiology A successful track record of strong sales performance. Specialty product launch experience Understanding of buy and bill and specialty channel distribution is preferred. Hospital / Institution knowledge and expertise with pharmacy formulary processes. Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority. Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times. Excellent communication and listening skills. Collaboration: Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues. Customer Focus: Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge Execution: Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact. Critical Thinking: Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence. Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories. Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable. Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • Overview We are looking for experienced Business Account Executives (B... Read More
    Overview We are looking for experienced Business Account Executives (BAEs) with specialty sales experience to promote AMVUTTRA. hATTR patients often spend years undiagnosed and misdiagnosed. This is an amazing opportunity to educate and enhance the market's knowledge of hATTR amyloidosis. In addition, this important role will be a collaborative partner to the local strategic team that supports the account. The BAE (TTR BAE) will be principally responsible for identifying and/or targeting healthcare providers and accounts managing and treating patients with TTR amyloidosis to develop plans to increase brand awareness and product adoption within their assigned territory. The BAE will be responsible for achieving territory targets and other business objectives through account and customer strategies, while also partnering can drive agreement/decisions from multiple stakeholders; can read people's emotions and flex communication style. Adjusts their approach based on different stakeholder needs, concerns, or audience member to drive alignment and meet their work goals. Effectively communicates and closely collaborates with stakeholders across commercial, compliance, legal, market access, and patient care centers to help ensure access at site of care. Builds individual account plans for key accounts and physicians including how to approach those customers, achieve sales goals, and maximize sales results. Collaborates with key accounts and physicians to drive patient identification through market development and physician education; develop a territory strategy to retain customers. Effectively utilizes resources such as programs, in-services, and in office presentations to impact territory results. Demonstrates and upholds the highest standards of integrity and compliance. Additional responsibilities as required to support business needs and organizational priorities. Qualifications 4-year degree from an accredited college or university required. MBA/Science Degree preferred. 5+ years of progressive and successful business experience in biotech or the specialty pharmaceutical industry. Experience in Cardiology A successful track record of strong sales performance. Specialty product launch experience Understanding of buy and bill and specialty channel distribution is preferred. Hospital / Institution knowledge and expertise with pharmacy formulary processes. Experience in driving, leading and delivering upon territory-level cross functional business planning and influencing without authority. Demonstrates adherence to all company policies, industry regulations, and ethical standards, ensuring compliant business practices at all times. Excellent communication and listening skills. Collaboration: Builds strong relationships with internal teams, contributes insights, and independently and proactively engages cross-functional partners to solve issues. Customer Focus: Consistently tailors brand messaging by learning customer needs and preferences while deepening product knowledge and market knowledge Execution: Takes ownership of territory, aligns goals with regional objectives, and develops detailed, customer-focused business plans that are continuously reviewed for impact. Critical Thinking: Utilizes data analysis tools to identify sales trends, anticipate risks, refine strategies, and make informed decisions with growing independence. Must be comfortable spending 60% of time traveling; some overnight travel required including travel to Boston, congresses and within large geographical territories. Driving is an essential duty of the job; candidates must have a valid driver's license to be considered and be insurable. Must live within assigned territory. #LI-Remote #LI-ST1 U.S. Pay Range $144,500.00 - $195,500.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less
  • Associate Scientist II, Protein Sciences  

    - Middlesex County
    Overview We are seeking an associate scientist-II to join our protein... Read More
    Overview We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein expression, purification, and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment.The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities This lab-based position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142 Key Responsibilities Work closely with the protein sciences team to engineer and validate binding of antibodies and antibody conjugates at various production scales. Design, plan, and perform protein binding experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members. Utilize UV-Vis spectroscopy and HPLC to analyze, quantify, characterize, and formulate protein conjugates. Contribute to the maintenance of laboratory infrastructure and equipment. Support group organization, productivity, and expertise through collaboration and idea exchange. Meet quality, quantity, and timeline expectations for all assigned projects. Support discovery efforts in protein sciences. Maintain accurate and complete electronic notebook records. Communicate experimental plans and data to multiple cross-functional scientific teams. Qualifications BS/MS degree in biology, biochemistry, biophysics, chemistry, or a related field, with 0-1 years of relevant laboratory experience in a biopharma or academic setting. Familiarity with protein and/or antibody structure and function. Experience with protein binding techniches (ELISA, flow cytometry, SPR and/or BLI) preferred. Experience with instrumentation such as Octet, Biacore, flow cytometers, and UV-Vis spectrometeters preferred. Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, IEX, SDS-PAGE, UV-Vis spectroscopy) preferred. Experience with sterile technique and/or handling mammalian cell culture is a plus. Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems. Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting. Effective written and oral communication skills. #LI-JR1 U.S. Pay Range $67,600.00 - $101,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. > Read Less

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